2-lactoyloxy-propionic acid ethyl ester | 65002-62-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 2-lactoyloxy-propionic acid ethyl ester
• 英文别名: 2-Lactoyloxy-propionsaeure-aethylester；Lactylmilchsaeure-aethylester；lactic acid dimer ethyl ester；di-lactic acid ethyl ester；ethyl lactyllactate；1-Ethoxy-1-oxopropan-2-yl 2-hydroxypropanoate；(1-ethoxy-1-oxopropan-2-yl) 2-hydroxypropanoate
• CAS: 65002-62-2
• 化学式: C₈H₁₄O₅
• 分子量: 190.196
• InChiKey: LXKMKDXPTRHJCP-UHFFFAOYSA-N

物化性质

• 沸点：
  269.5±15.0 °C(Predicted)
• 密度：
  1.147±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-lactoyloxy-propionic acid ethyl ester 、 己二酰氯 在 吡啶 、 乙醚 作用下， 生成 adipic acid bis-[1-(1-ethoxycarbonyl-ethoxycarbonyl)-ethyl ester]
  参考文献：
  名称：

  Diesters of Lactic Acid. Adipates of Various Lactates^1,2

  摘要：

  DOI：

  10.1021/ja01168a513
• 作为产物：
  描述：

  乳酸乙酯 在 硫酸 作用下， 生成 2-lactoyloxy-propionic acid ethyl ester
  参考文献：
  名称：

  Diesters of Lactic Acid. Adipates of Various Lactates^1,2

  摘要：

  DOI：

  10.1021/ja01168a513

文献信息

• [EN] DRUGS AND COMPOSITIONS FOR THE TREATMENT OF OCULAR DISORDERS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES OCULAIRES
  申请人：GRAYBUG VISION INC

  公开号：WO2018175922A1

  公开（公告）日：2018-09-27

  The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

  本发明提供了治疗活性化合物的新前药，包括寡聚前药，以及用于治疗医学疾病的组合物，例如青光眼，一种与眼压增高有关的疾病或异常，需要神经保护的疾病，年龄相关性黄斑变性，或糖尿病性视网膜病变。
• Biocompatible oligomer-polymer compositions
  申请人：Norton Richard L.

  公开号：US09308162B2

  公开（公告）日：2016-04-12

  The present invention relates to biocompatible oligomer-polymer compositions for the in situ formation of implants, wherein the implants release a bioactive agent, a metabolite, or a prodrug thereof, at a controlled rate. The sustained release delivery system includes a flowable composition containing a bioactive agent, a metabolite, or a prodrug thereof, and an implant containing a bioactive agent, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, a biocompatible end-capped oligomeric liquid, and a bioactive agent, a metabolite, or a prodrug thereof.

  本发明涉及生物相容性寡聚物-聚合物组合物，用于原位形成植入物，其中植入物以受控速率释放生物活性剂、代谢物或其前药。持续释放输送系统包括含有生物活性剂、代谢物或其前药的可流动组合物，以及含有生物活性剂、代谢物或其前药的植入物。可将可流动组合物注入组织中，使其凝结成为固体或凝胶、单体植入物。可流动组合物包括可生物降解的热塑性聚合物、生物相容性末端封端的寡聚物液体，以及生物活性剂、代谢物或其前药。
• APPLICATIONS OF BIOBASED GLYCOL COMPOSITIONS
  申请人：Binder Thomas Paul

  公开号：US20080103340A1

  公开（公告）日：2008-05-01

  A biobased replacement for propylene glycol and ethylene glycol derived from petrochemical sources is presented. The product mixture from the hydrogenolysis of certain polyols from biobased renewable resources may replace propylene glycol and ethylene glycol products from petrochemical sources. Applications and methods of the biobased hydrogenolysis product mixture are disclosed. The compositions and methods provide a feedstock for industrial use which has a 13 C/ 12 C isotope ratio characteristic of bioderived material.

  提出了一种基于生物的替代品，用于丙二醇和乙二醇，这些替代品源自石化来源。从基于生物可再生资源中的某些多元醇的氢解反应产生的产物混合物可以替代石化来源的丙二醇和乙二醇产品。公开了基于生物氢解产物混合物的应用和方法。这些组合物和方法提供了一个13C/12C同位素比特征为生物衍生材料的工业用原料。
• TRANSESTERIFICATION PROCESS USING MIXED SALT ACETYLACETONATES CATALYSTS
  申请人：Goossens Thomas Peter Anne

  公开号：US20130090492A1

  公开（公告）日：2013-04-11

  This invention is directed to a general catalyst of high activity and selectivity for the production of a variety of esters, particularly acrylate and methacrylate-based esters, by a transesterification reaction. This objective is achieved by reaction of an ester of a carboxylic or a carbonic acid, in particular of a saturated or unsaturated, typically, a 3 to 4 carbon atom carboxylic acid; with an alcohol in the presence of a catalyst comprising the combination of a metal 1,3-dicarbonyl complex (pref. Zn or Fe acetylacetonate) and a salt, in particular an inorganic salt, pref. ZnCl2, LiCI, NaCI, NH4CI or Lil. These catalysts are prepared from readily available starting materials within the reaction medium without the need for isolation (in-situ preparation).

  这项发明针对一种高活性和选择性的通用催化剂，用于通过酯交换反应生产各种酯类，特别是丙烯酸酯和甲基丙烯酸酯。该目标通过在存在催化剂的情况下，将羧酸酯或碳酸酯的酯，特别是饱和或不饱和的、通常为3到4个碳原子的羧酸酯；与醇反应来实现。催化剂包括金属1,3-二羰基配合物（首选Zn或Fe乙酰丙酮酸盐）和盐的组合，特别是无机盐，首选ZnCl2，LiCl，NaCl，NH4Cl或I2。这些催化剂是在反应介质中从易得的起始物质制备而成，无需分离（原位制备）。
• Process for production of organic acid esters
  申请人：Miller J. Dennis

  公开号：US20060014977A1

  公开（公告）日：2006-01-19

  A process for producing organic acid esters using continuous countercurrent reactive distillation using acid catalysts in a structured packing in a single column ( 10 ) is described. In the reactive distillation an organic acid ester is formed by chemical reaction and can be purified to its final state within the single column. Organic acid esters are produced at relatively low cost, with less waste production, and in a less complicated manner than prior processes. Organic acid ester have uses as solvents, as intermediate chemicals, and in consumer products.

  描述了一种利用酸性催化剂在单一柱中使用结构填料进行连续逆流反应蒸馏生产有机酸酯的工艺。在反应蒸馏中，通过化学反应形成有机酸酯，并可以在单一柱内将其纯化至最终状态。有机酸酯的生产成本相对较低，废物产生较少，且比以往的工艺更简单。有机酸酯可用作溶剂、中间化学品以及消费品。