(S)-N-(4-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetamido)butyl)-5-oxopyrrolidine-2-carboxamide | 1284260-15-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-N-(4-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetamido)butyl)-5-oxopyrrolidine-2-carboxamide
• CAS: 1284260-15-6
• 化学式: C₂₂H₂₇Cl₂N₃O₅
• 分子量: 484.379
• InChiKey: AMJBGDRHMXLHTH-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.81
• 重原子数：
  32.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  113.6
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  利尿酸 在 10% palladium on activated charcoal 、 氢气 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.83h， 生成 (S)-N-(4-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetamido)butyl)-5-oxopyrrolidine-2-carboxamide
  参考文献：
  名称：

  Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries

  摘要：

  The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid butyl amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs were found to have a good anti-tumor activity comparable to cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.068