The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H.
摘要:
从五味子果实中分离得到四种新的二苯并环辛二烯木酚素:当归酰-(1)、替格洛酰-(2)、苯甲酰-gomisin H (3) 和gomisin H (4)。 (五味子科)。通过化学和光谱技术阐明了它们的结构。
The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H.
摘要:
从五味子果实中分离得到四种新的二苯并环辛二烯木酚素:当归酰-(1)、替格洛酰-(2)、苯甲酰-gomisin H (3) 和gomisin H (4)。 (五味子科)。通过化学和光谱技术阐明了它们的结构。
The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.
Methods of application of chemical compounds having therapeutic activities in treating cancers
申请人:Hu Xun
公开号:US20050282910A1
公开(公告)日:2005-12-22
Methods of application of a class of compounds with a pharmacophore of dibenzocyclooctadiene in the preparation of anticancer medications, and particularly for the preparation of medications for the treatment of P-glycoprotein-mediated multidrug resistant (MDR) cancer and non-P-glycoprotein-mediated MDR cancer, such as multidrug resistant associated protein MRP1-mediated cancer. Methods of increasing the efficacy of anticancer agents are further disclosed. The class of compounds are of a potency to effectively reverse MDR cancer by inhibiting the drug transport activity of an ABC drug transporter, increase the intracellular accumulation of an anticancer agent in MDR cancer cells, enhance apoptosis of cancer cells induced by an anticancer agent, and directly kill cancer cells. The aforementioned methods of application of the present disclosure provide much potential for the treatment of cancer. Mass production of medications incorporating these chemical compounds will treat a significant number of patients affected by the condition of MDR cancer.
ATR Inhibitor
申请人:Nishida Hiroshi
公开号:US20100048923A1
公开(公告)日:2010-02-25
The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.