gomisin H | 66056-20-0

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: gomisin H
• 英文别名: (9S,10S)-4,5,14,15,16-pentamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-3,10-diol
• CAS: 66056-20-0
• 化学式: C₂₃H₃₀O₇
• 分子量: 418.487
• InChiKey: NLJJSPKWNBUDNS-MYODQAERSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

制备方法与用途

生物活性方面，Gomisin H 是一种从 Schizandra chinensis BAILL 提取的联苯环辛二烯类木脂素。

反应信息

• 作为反应物：
  描述：

  gomisin H 在 platinum(IV) oxide 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (6S,7S)-1,2,3,10,11-Pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cycloocten-6-ol
  参考文献：
  名称：

  The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H.

  摘要：

  从五味子果实中分离得到四种新的二苯并环辛二烯木酚素：当归酰-(1)、替格洛酰-(2)、苯甲酰-gomisin H (3) 和gomisin H (4)。 （五味子科）。通过化学和光谱技术阐明了它们的结构。

  DOI：

  10.1248/cpb.27.1576
• 作为产物：
  描述：

  Benzoyl-gomisin-H 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 gomisin H
  参考文献：
  名称：

  The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H.

  摘要：

  从五味子果实中分离得到四种新的二苯并环辛二烯木酚素：当归酰-(1)、替格洛酰-(2)、苯甲酰-gomisin H (3) 和gomisin H (4)。 （五味子科）。通过化学和光谱技术阐明了它们的结构。

  DOI：

  10.1248/cpb.27.1576

文献信息

• ATR INHIBITOR
  申请人：Niigata TLO Corporation

  公开号：EP1946757A1

  公开（公告）日：2008-07-23

  The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.

  本发明旨在提供一种 ATR 抑制剂，其活性成分中含有三环化合物，包括 Schizandrins 和 Gomisins，可用于 ATR 蛋白激酶抑制剂。
• JP1042421A
  申请人：——

  公开号：JP1042421A

  公开（公告）日：1989-02-14
• JPS6442421A
  申请人：——

  公开号：JPS6442421A

  公开（公告）日：1989-02-14
• Methods of application of chemical compounds having therapeutic activities in treating cancers
  申请人：Hu Xun

  公开号：US20050282910A1

  公开（公告）日：2005-12-22

  Methods of application of a class of compounds with a pharmacophore of dibenzocyclooctadiene in the preparation of anticancer medications, and particularly for the preparation of medications for the treatment of P-glycoprotein-mediated multidrug resistant (MDR) cancer and non-P-glycoprotein-mediated MDR cancer, such as multidrug resistant associated protein MRP1-mediated cancer. Methods of increasing the efficacy of anticancer agents are further disclosed. The class of compounds are of a potency to effectively reverse MDR cancer by inhibiting the drug transport activity of an ABC drug transporter, increase the intracellular accumulation of an anticancer agent in MDR cancer cells, enhance apoptosis of cancer cells induced by an anticancer agent, and directly kill cancer cells. The aforementioned methods of application of the present disclosure provide much potential for the treatment of cancer. Mass production of medications incorporating these chemical compounds will treat a significant number of patients affected by the condition of MDR cancer.
• ATR Inhibitor
  申请人：Nishida Hiroshi

  公开号：US20100048923A1

  公开（公告）日：2010-02-25

  The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.