老鹳草素 | 60976-49-0

• 物质功能分类: 天然产物 - 酚类
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 中文名称: 老鹳草素
• 中文别名: 牛儿鞣素
• 英文名称: (1,13,14,15,18,19,20,34,35,39,39-undecahydroxy-2,5,10,23,31-pentaoxo-6,9,24,27,30,40-hexaoxaoctacyclo[34.3.1.04,38.07,26.08,29.011,16.017,22.032,37]tetraconta-3,11,13,15,17,19,21,32,34,36-decaen-28-yl) 3,4,5-trihydroxybenzoate
• CAS: 60976-49-0
• 化学式: C₄₁H₂₈O₂₇
• 分子量: 952.6
• InChiKey: JQQBXPCJFAKSPG-UHFFFAOYSA-N

物化性质

• 密度：
  2.25
• 溶解度：
  DMSO：100 mg/mL（104.97 mM；需要超声波）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  68
• 可旋转键数：
  3
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  450
• 氢给体数：
  14
• 氢受体数：
  27

安全信息

• 海关编码：
  2932999099
• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

制备方法与用途

分布

老鹳草素主要存在于牻牛儿苗科和大戟科植物中。无患子科、睡莲科和杜英科等科也检测到其存在，但集中度较低。在牻牛儿苗科中，老鹳草素尤其集中在老鹳草属植物中；而在大戟科中，则主要存在于叶下珠属植物中。总体而言，与大戟科相比，牻牛儿苗科中老鹳草素的分布更为广泛。

作用

老鹳草素在体外具有较高的抗氧化活性，能够清除DPPH自由基、羟自由基和超氧自由基。

用途

老鹳草素可以抑制转化生长因子TGF-β1诱导的上皮间充质干细胞的转化，并且能够抑制人肺癌A549细胞的迁移、侵袭及抗脱落凋亡作用。此外，它还具有抗氧化和止泻等功效。

化学性质

老鹳草素为白色粉末状物质，可溶于甲醇、乙醇和DMSO等多种有机溶剂。该化合物来源于大戟科油柑属植物叶下珠（Phyllanthus urinaria L.）的全株部分。

用途

老鹳草素不仅适用于含量测定/鉴定及药理实验等科学研究，还具有抗氧化、止泻等多种实际应用价值，其药理药效包括抗氧化和止泻。

文献信息

• Novel Phyllanthus Extract
  申请人：Katz Aron

  公开号：US20100190726A1

  公开（公告）日：2010-07-29

  A method is described for producing an extract of Phyllanthus comprising the steps of: (a) extracting Phyllanthus components with a solvent; (b) fractionating the extract obtained in the preceding step on the basis of hydrophobicity; (c) collecting and combining fractions that correspond in hydrophobicity to elute fractions resulting from 10-50% methanol elution steps, wherein the elute fractions are obtained by low pressure vacuum liquid chromatography (VLC) using a C18 reversed-phase lipophilic column and a water/methanol gradient system, wherein the gradient system is based on an initial elution step of loading the column with 100% water, on intermediate elution steps with gradually decreasing water content and on a terminal elution step loading the column with 100% methanol; and (d) optionally drying the extract obtained in step (c). The invention also relates to an extract of Phyllanthus obtainable or obtained by the method or a fraction thereof and a Phyllanthus extract or fraction thereof comprising repandusinic acid, wherein the repandusinic acid is present at a concentration of at least 42 mg/g.
• PHYLLANTHUS AMARUS COMPOSITIONS AND METHOD OF EXTRACTING SAME
  申请人：Natreon, Inc.

  公开号：US20130122119A1

  公开（公告）日：2013-05-16

  An enriched hydrolyzable tannin blend derived from Phyllanthus amarus is provided. An optimized aqueous extraction method for Phyllanthus amarus is provided to maximize the levels of bioactive hydrolyzable tannins including corilagin, geraniin, nirurin and other low molecular weight hydrolyzable tannoids. The method produces a Phyllanthus amarus extract containing a hydrolyzable tannin blend as an amorphous dry powder. In an embodiment, the Phyllanthus amarus extract contains 7-13% by weight corilagin, 3.5-10% nirurin, 1-2% geraniin, and 9-20% low molecular weight hydrolyzable tannoids. In another embodiment, the Phyllanthus amarus extract contains 12-20% geraniin and 12-20% low molecular weight hydrolyzable tannoids. Potential uses of said enriched hydrolyzable tannin compositions for hepatoprotection in a human subject are described herein.
• ANTICANCER AGENT, AND COMBINATION USE ANTICANCER AGENT
  申请人：Microbial Chemistry Research Foundation

  公开号：US20150283159A1

  公开（公告）日：2015-10-08

  An anticancer agent containing ellagitannin, a combination use anticancer agent wherein the anticancer agent and an anticancer agent containing anthracyclines are used in combination.
• US8366935B2
  申请人：——

  公开号：US8366935B2

  公开（公告）日：2013-02-05