1-((2R,3R,4R)-4-((叔丁基二甲基硅烷基)氧基)-3-氟-5,5-双(羟甲基) | 1445379-61-2
中文名称
1-((2R,3R,4R)-4-((叔丁基二甲基硅烷基)氧基)-3-氟-5,5-双(羟甲基)
中文别名
——
英文名称
4'-α-methylhydroxyl-3'-tert-butyldimethylsilyl-2'-deoxy-2'-fluorouridine
英文别名
1-((2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione；1-[(2R,3R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-3-fluoro-5,5-bis(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
CAS
1445379-61-2
化学式
C16H27FN2O6Si
mdl
——
分子量
390.484
InChiKey
FQCJMRIFHYTBRI-FRRDWIJNSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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密度：1.27±0.1 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：0.52
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重原子数：26
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可旋转键数：6
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环数：2.0
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sp3杂化的碳原子比例：0.75
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拓扑面积：108
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氢给体数：3
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氢受体数：7
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 2'-氟-2'-脱氧尿苷 2'-deoxy-2'-fluorouridine 784-71-4 C9H11FN2O5 246.195 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 1-((2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5,5-bis(((tert-butyldimethylsilyl)oxy)methyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445379-82-7 C28H55FN2O6Si3 619.009 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445379-98-5 C32H45FN2O5Si2 612.889 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445379-78-1 C33H47FN2O5Si2 626.916 —— 1-((2R,3R,4R,5S)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(1-hydroxyethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445387-29-0 C33H47FN2O6Si2 642.915 —— 1-((2R,3R,4R,5R)-5-butyl-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445387-17-6 C35H51FN2O5Si2 654.97 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-isopropyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445387-52-9 C34H49FN2O5Si2 640.943 —— ALS-8112 1445379-94-1 C10H12ClFN2O5 294.667 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethynyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445380-56-2 C33H43FN2O5Si2 622.884 —— 1-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-ethenyl-3-fluorooxolan-2-yl]pyrimidine-2,4-dione 1445379-68-9 C33H45FN2O5Si2 624.9 —— (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-carbaldehyde 1445379-66-7 C32H43FN2O6Si2 626.873 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445384-15-5 C34H47FN2O5Si2 638.927 —— 1-((2R,3R,4R,5S)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(1-hydroxyprop-2-yn-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445380-06-2 C34H45FN2O6Si2 652.911 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445379-96-3 C32H44FIN2O5Si2 738.786 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445380-08-4 C34H45FN2O5Si2 636.911 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445380-00-6 C32H46FN3O4Si2 611.904 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(2-chlorovinyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445380-54-0 C33H44ClFN2O5Si2 659.345 —— 1-((2R,3R,4R,5R)-5-(but-1-en-1-yl)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445386-82-2 C35H49FN2O5Si2 652.954 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(3-methylbut-1-en-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445396-36-0 C36H51FN2O5Si2 666.981 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445379-72-5 C33H48FN3O4Si2 625.931 —— 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(prop-1-en-2-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445387-33-6 C34H47FN2O5Si2 638.927 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-vinyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445379-70-3 C33H46FN3O4Si2 623.915 4-氨基-1-((2R,3R,4R,5R)-4-((叔丁基二甲基硅烷基)氧基)-5-(( 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445379-90-7 C32H45ClFN3O4Si2 646.349 —— [(2R,3R,4R,5R)-3-acetyloxy-2-(chloromethyl)-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-2-yl]methyl acetate 1445390-24-8 C14H16ClFN2O7 378.742 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445384-18-8 C34H48FN3O4Si2 637.942 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445380-10-8 C34H46FN3O4Si2 635.926 —— 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445381-19-0 C24H24F2N2O5 458.462 —— 2'-deoxy-2'-fluoro-4'-fluoromethylcytidine 1445381-31-6 C10H13F2N3O4 277.228 —— 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(3-methylbut-1-en-1-yl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1445396-41-7 C36H52FN3O4Si2 665.996 —— [(2R,3R,4R,5R)-3-acetyloxy-2-(chloromethyl)-4-fluoro-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate 1445390-34-0 C14H15ClF2N2O7 396.732 —— 3-benzoyl-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-vinyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445384-12-2 C40H49FN2O6Si2 729.008