2-甲基-6-肼基吡啶 | 5315-24-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-甲基-6-肼基吡啶
• 中文别名: 2-肼基-6-甲基吡啶
• 英文名称: 2-hydrazino-6-methylpyridine
• 英文别名: 2-hydrazinyl-6-methylpyridine；2-hydrazineyl-6-methylpyridine；2-Hydrazino-6-methyl-pyridin；(6-methylpyridin-2-yl)hydrazine
• CAS: 5315-24-2
• 化学式: C₆H₉N₃
• 分子量: 123.158
• InChiKey: RDVGWJKUYXVTSO-UHFFFAOYSA-N

物化性质

• 熔点：
  54-56 °C
• 沸点：
  80-85 °C(Press: 0.5 Torr)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090
• 储存条件：
  -20°C，密封保存于干燥且惰性气体环境中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Hydrazinyl-6-methylpyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Hydrazinyl-6-methylpyridine
CAS number: 5315-24-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H9N3
Molecular weight: 123.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-甲基-6-肼基吡啶 在 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 3.0h， 以1.15 g的产率得到5-methyltetrazolo[1,5-a]pyridine
  参考文献：
  名称：

  基于铁（II）的金属铁活化：从传统的点击化学转换为脱氮环化

  摘要：

  通过催化量的Fe（TPP）Cl和Zn粉尘发现了1,2,3,4-四唑和炔烃的分子间脱氮环化的独特概念。该反应排除了有机叠氮化物和炔烃之间传统的，更受欢迎的点击反应，而是通过空前的金属-金属活化来进行。预计该方法将促进重要的基本氮杂环的构建，而这反过来又可以发现新的候选药物。

  DOI：

  10.1002/anie.201904702
• 作为产物：
  描述：

  2-溴-6-甲基吡啶 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2-甲基-6-肼基吡啶
  参考文献：
  名称：

  基于铁（II）的金属铁活化：从传统的点击化学转换为脱氮环化

  摘要：

  通过催化量的Fe（TPP）Cl和Zn粉尘发现了1,2,3,4-四唑和炔烃的分子间脱氮环化的独特概念。该反应排除了有机叠氮化物和炔烃之间传统的，更受欢迎的点击反应，而是通过空前的金属-金属活化来进行。预计该方法将促进重要的基本氮杂环的构建，而这反过来又可以发现新的候选药物。

  DOI：

  10.1002/anie.201904702
• 作为试剂：
  描述：

  在 甲醇 、 水 、 sodium cyanoborohydride 、 2-甲基-6-肼基吡啶 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 1-(2,6-dichlorophenyl)-4-((6-((1,1-dioxidothiomorpholino)methyl)pyridin-3-yl)amino)-1H-pyrazole-3-carboxamide
  参考文献：
  名称：

  [EN] KINASE MODULATORS AND METHODS OF USE THEREOF
  [FR] MODULATEURS DE KINASE ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  本发明涉及一种新颖的化合物，可调节一个或多个激酶的活性，例如TYK2或其突变体。这些化合物可能是激酶抑制剂或激活剂，用于治疗自身免疫性疾病，例如银屑病、红斑狼疮、多发性硬化和炎症性肠病。

  公开号：

  WO2022011337A1

文献信息

• Triazolone derivatives
  申请人：Clark Richard

  公开号：US20080015199A1

  公开（公告）日：2008-01-17

  A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.; R 2 represents optionally substituted phenyl, etc.; R 3 represents optionally substituted C6-10 aryl, etc.; and Z 1 and Z 2 each independently represent hydrogen]

  以下一般式（1）表示的化合物，其盐或上述化合物的水合物是一种新型化合物，可用于治疗和/或预防与血栓形成相关的疾病，并且具有适当的物理化学稳定性，更安全。 [其中R1a，R1b，R1c和R1d分别独立表示氢等；R2表示可选择取代的苯基等；R3表示可选择取代的C6-10芳基等；Z1和Z2分别独立表示氢]
• Condensed pyrazole derivatives, process for producing the same and use thereof
  申请人：——

  公开号：US20030187014A1

  公开（公告）日：2003-10-02

  Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): 1 or salts thereof.

  用于抑制Th2选择性免疫应答的新型药物组合物和包括由一般式(I)表示的紧缩吡唑烷衍生物的药物组合物，或其盐。
• 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途
  申请人：四川科伦博泰生物医药股份有限公司

  公开号：CN112694477A

  公开（公告）日：2021-04-23

  本发明属于药物化学领域，涉及吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途。具体而言，本发明提供了一种具有式I结构的化合物，其表现出较好的TGFβR1抑制活性及较高的选择性，可以作为高效且高选择性的TGFβR1抑制剂，具有抗肿瘤活性。
• [EN] TRICYCLIC PSYCHOPLASTOGENS AND USES THEREOF<br/>[FR] PSYCHOPLASTOGÈNES TRICYCLIQUES ET LEURS UTILISATIONS
  申请人：DELIX THERAPEUTICS INC

  公开号：WO2021252691A1

  公开（公告）日：2021-12-16

  Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and/or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and/or plasticity, such as neurological diseases and disorders, with non-hallucinogenic psychoplastogens.

  本文披露了一些化合物、组合物和方法，用于促进神经元生长和/或改善神经元结构，所述化合物和组合物。还描述了使用非致幻性精神塑形剂治疗由突触连接丧失和/或可塑性介导的疾病或障碍的方法，如神经系统疾病和障碍。
• [EN] ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES<br/>[FR] CONJUGUÉS D'ANTICORPS-INHIBITEUR ALK5 ET LEURS UTILISATIONS
  申请人：SYNTHIS LLC

  公开号：WO2020013803A1

  公开（公告）日：2020-01-16

  The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

  本公开涉及包含ALK5抑制剂的抗体药物偶联物及其用途。