tridecyl mesylate | 62732-69-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: tridecyl mesylate
• 英文别名: Tridecyl methanesulfonate
• CAS: 62732-69-8
• 化学式: C₁₄H₃₀O₃S
• 分子量: 278.456
• InChiKey: QZWUDZRPDWSGQI-UHFFFAOYSA-N

物化性质

• 沸点：
  385.5±11.0 °C(Predicted)
• 密度：
  0.970±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tridecyl mesylate 在 copper(l) iodide 、 四(三苯基膦)钯 、 sodium hydride 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 24.0h， 生成 Cf 3232
  参考文献：
  名称：

  Novel Antiviral Activity of l-Dideoxy Bicyclic Nucleoside Analogues versus Vaccinia and Measles Viruses in Vitro

  摘要：

  Dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with D-chirality have previously been described by us to inhibit replication of human cytomegalovirus. We herein report for the first time that activity against vaccinia virus (VACV) was achieved using novel L-analogues. A structure-activity relationship was established: Antiviral activity versus VACV was highest with an ether side chain with an optimum of n-C9H18-O-n-C5H11. This gave an IC50 of 190 nM, a 60-fold enhancement over the FDA-approved antiviral cidofovir. Interestingly, L-ddBCNAs also inhibit wild type measles virus syncytia formation with a TCID50 of 7.5 mu M for the lead compound. We propose that L-ddBCNAs represent significant innovative antiviral candidates versus measles and poxviruses, and we suggest a mechanism of action versus one or more cellular targets that are essential for viral replication.

  DOI：

  10.1021/jm301778x
• 作为产物：
  描述：

  十三烷醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以93%的产率得到tridecyl mesylate
  参考文献：
  名称：

  Novel Antiviral Activity of l-Dideoxy Bicyclic Nucleoside Analogues versus Vaccinia and Measles Viruses in Vitro

  摘要：

  Dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with D-chirality have previously been described by us to inhibit replication of human cytomegalovirus. We herein report for the first time that activity against vaccinia virus (VACV) was achieved using novel L-analogues. A structure-activity relationship was established: Antiviral activity versus VACV was highest with an ether side chain with an optimum of n-C9H18-O-n-C5H11. This gave an IC50 of 190 nM, a 60-fold enhancement over the FDA-approved antiviral cidofovir. Interestingly, L-ddBCNAs also inhibit wild type measles virus syncytia formation with a TCID50 of 7.5 mu M for the lead compound. We propose that L-ddBCNAs represent significant innovative antiviral candidates versus measles and poxviruses, and we suggest a mechanism of action versus one or more cellular targets that are essential for viral replication.

  DOI：

  10.1021/jm301778x

文献信息

• Silver halide colour photographic material and cyan coupler of the 2-phenylureido-5-acylaminophenol type
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0423764A2

  公开（公告）日：1991-04-24

  There is disclosed a silver halide color photographic material having a silver halide emulsion layer on a base which comprises a novel cyan coupler. According to the disclosure, a silver halide color photographic material containing a cyan coupler that has high coupling reactivity and high color density, resulting color image being hardly susceptible to reduction fading and is excellent in heat fast can be obtained.

  本发明公开了一种卤化银彩色感光材料，该材料在包含新型青色耦合剂的基底上具有卤化银乳剂层。根据本发明，可以获得一种含有青色耦合剂的卤化银彩色感光材料，它具有高耦合反应活性和高色彩密度，所产生的彩色图像几乎不易还原褪色，而且耐热性能极佳。
• LUBRICATING OIL ADDITIVE, LUBRICATING OIL COMPOSITION CONTAINING THE SAME, VARIOUS LOW-FRICTION SLIDING MEMBERS, ROLLING BEARING, AND SLIDING BEARING
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP2011853A1

  公开（公告）日：2009-01-07

  Provided is an additive for lubricating oils which enhances frictional characteristics of slide parts in internal combustion engines and driving system transmission engines and which exhibit an excellent fuel consumption reducing effect. The above additive for lubricating oils comprises a heterocyclic compound having a heterocyclic skeleton originating in a compound selected from pyridines, pyrroles, pyrimidines, pyrazoles, pyridazines, indazoles, pyrazines, triazines, triazoles, tetrazoles, oxazoles, oxadiazoles, thiazoles, thiadiazoles, furans, dioxanes, pyrans and thiophenes. A lubricating oil composition containing the above additive for lubricating oils is effectively used for various low friction slide members, antifriction bearings and slide bearings.

  本发明提供了一种润滑油添加剂，它能增强内燃机和驱动系统传动发动机中滑动部件的摩擦特性，并具有出色的降低油耗效果。上述润滑油添加剂包含一种杂环化合物，其杂环骨架源自选自吡啶、吡咯、嘧啶、吡唑、哒嗪、吲唑、吡嗪、三嗪、三唑、四唑、噁唑、噁二唑、噻唑、噻二唑、呋喃、二噁烷、吡喃和噻吩的化合物。含有上述润滑油添加剂的润滑油组合物可有效地用于各种低摩擦滑动部件、减摩轴承和滑动轴承。
• Vill, Volkmar; Weber, Nikolaus, Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 250, p. 73 - 84
  作者：Vill, Volkmar、Weber, Nikolaus

  DOI：——

  日期：——
• Regioselective Synthesis of 3-O-Alkyl Ethers of Ascorbic Acid without Protecting Groups in a Single Step
  作者：Uwe Beifuss、Olaf Kunz、Gundula Voss

  DOI：10.1016/s0040-4020(99)01013-3

  日期：2000.1

  The direct alkylation of L-ascorbic acid (vitamin C) with alkyl mesylates using sodium hydrogen carbonate as a base without protecting groups proceeds regioselectively and yields the corresponding 3-O-alkyl ethers of L-ascorbic acid exclusively. (C) 2000 Elsevier Science Ltd. All rights reserved.
• US4473704A
  申请人：——

  公开号：US4473704A

  公开（公告）日：1984-09-25