5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol | 155021-30-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
• CAS: 155021-30-0
• 化学式: C₂₃H₂₈ClN₃O₅S*C₄₂H₇₀O₃₅
• 分子量: 1629.01
• InChiKey: MSMBJBWLDYETRE-ZQOBQRRWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.59
• 重原子数：
  110
• 可旋转键数：
  15
• 环数：
  24.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  676
• 氢给体数：
  24
• 氢受体数：
  40

反应信息

• 作为反应物：
  描述：

  5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol 生成 格列本脲 、 β-环糊精
  参考文献：
  名称：

  格列本脲与β-环糊精络合的伏安和分光光度法研究

  摘要：

  通过紫外分光光度法和差分脉冲伏安法研究了格列本脲 (GL) 与 β-环糊精 (β-CD) 在 pH 7.0 的乙醇缓冲水溶液中形成的包合物，其稳定性常数确定为 855 和 354.15 M-1，分别。基于分光光度吸光度的变化，相溶解度分布被归类为 AL 型，表明格列本脲与 β-CD 的 1:1 化学计量包合物的形成，其稳定性常数值 KS 为 846 M-1。

  DOI：

  10.1007/s10847-010-9801-9
• 作为产物：
  描述：

  格列本脲 、 β-环糊精 生成 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
  参考文献：
  名称：

  格列本脲与β-环糊精络合的伏安和分光光度法研究

  摘要：

  通过紫外分光光度法和差分脉冲伏安法研究了格列本脲 (GL) 与 β-环糊精 (β-CD) 在 pH 7.0 的乙醇缓冲水溶液中形成的包合物，其稳定性常数确定为 855 和 354.15 M-1，分别。基于分光光度吸光度的变化，相溶解度分布被归类为 AL 型，表明格列本脲与 β-CD 的 1:1 化学计量包合物的形成，其稳定性常数值 KS 为 846 M-1。

  DOI：

  10.1007/s10847-010-9801-9

文献信息

• Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin
  作者：Abd-Elgawad Radi、Shimaa Eissa

  DOI：10.1007/s10847-010-9801-9

  日期：2010.12

  The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M−1, respectively. The phase solubility profile, based on the spectrophotometric absorbance’s variations, was classified as

  通过紫外分光光度法和差分脉冲伏安法研究了格列本脲 (GL) 与 β-环糊精 (β-CD) 在 pH 7.0 的乙醇缓冲水溶液中形成的包合物，其稳定性常数确定为 855 和 354.15 M-1，分别。基于分光光度吸光度的变化，相溶解度分布被归类为 AL 型，表明格列本脲与 β-CD 的 1:1 化学计量包合物的形成，其稳定性常数值 KS 为 846 M-1。