quercetin-3-O-D-glucoside-7-O-D-glucoside | 6892-74-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: quercetin-3-O-D-glucoside-7-O-D-glucoside
• 英文别名: quercetin-3-O-glucoside-7-O-glucoside；quercetin-3,7-O-di-glucopyranoside；quercetin-3-glucoside-7-glucoside；quercetin-3,7-diglucopyranoside；quercetin 3,7-di-D-glucoside；quercetin 3,7-di-O-glucoside；2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-bis[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]chromen-4-one
• CAS: 6892-74-6；30311-60-5；56782-99-1；116004-33-2；125591-69-7
• 化学式: C₂₇H₃₀O₁₇
• 分子量: 626.525
• InChiKey: BNSCASRSSGJHQH-KBGHMCAJSA-N

物化性质

• 沸点：
  1049.9±65.0 °C(Predicted)
• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  286
• 氢给体数：
  11
• 氢受体数：
  17

制备方法与用途

槲皮素3,7-二葡萄糖苷是一种抗氧化剂，可以从无花果叶中提取得到。

反应信息

• 作为反应物：
  描述：

  quercetin-3-O-D-glucoside-7-O-D-glucoside 在 盐酸 、 水 作用下， 反应 1.0h， 生成 葡萄糖 、 槲皮素
  参考文献：
  名称：

  Flavonoids from Physospermum acteaefolium

  摘要：

  DOI：

  10.1007/s10600-012-0281-6
• 作为产物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 槲皮素 在 phosphate buffer 作用下， 反应 0.5h， 生成 quercetin-3-O-glucoside 、 quercetin-3-O-D-glucoside-7-O-D-glucoside
  参考文献：
  名称：

  Cloning and functional characterisation of two regioselective flavonoid glucosyltransferases from Beta vulgaris

  摘要：

  Two full-length cDNAs encoding flavonoid-specific glucosyltransferases, UGT73A4 and UGT71F1, were isolated from a cDNA library of Beta vulgaris (Amaranthaceac) cell suspension cultures. They displayed high identity to position-specific betanidin and flavonoid glucosyltransferases from Dorotheanthus bellidiformis (Aizoaceae) and to enzymes with similar substrate specificities from various plant families. The open reading frame of the sequences encode proteins of 476 (UGT73A4) and 492 (UGT71F1) amino acids with calculated molecular masses of 54.07 kDa and 54.39 kDa, and isoelectric points of 5.8 and 5.6, respectively. Both enzymes were functionally expressed in Escherichia coli as His- and GST-tagged proteins, respectively. They exhibited a broad substrate specificity, but a distinct regioselectivity, glucosylating a variety of flavonols, flavones, flavanones, and coumarins. UGT73A4 showed a preference for the 4'- and 7-OH position in the flavonoids, whereas UGT71F1 preferentially glucosylated the 3- or the 7-OH position. Glucosylation of betanidin, the aglycone of the major betacyanin, betanin, in B. vulgaris was also observed to a low extent by both enzymes. Several O-glycosylated vitexin derivatives isolated from leaves of young B. vulgaris plants and rutin obtained from B. vulgaris tissue culture are discussed as potential endogenous products of UGT73A4 and UGT71F1. The results are analyzed with regard to evolution and specificity of plant natural product glucosyltransferases., (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2006.06.026

文献信息

• Methods for treating benign prostatic hypertrophy (BPH) symptoms using extract from Ageratum spp
  申请人：GE Nutrients, Inc.

  公开号：US11071763B2

  公开（公告）日：2021-07-27

  An herbal extract and constituents thereof for treatment of BPH and related aging symptoms in males and for addressing male health using extracts from Ageratum spp., including, but not limited to, Ageratum conyzoides, Ageratum coeruleum and Ageratum houstonianum, is disclosed herein. At least one compound of plants, and parts of plants, of Ageratum spp., such as, but not limited to, N,N-bis(trimethylsilyl)-2-phenyl-7-(trifluoromethyl)quinolon-4-amine, 3′,4′,5′,6′,7′,8-hexamethoxyflavone, Phytol, Precocene, caryophyllene, squalene, alpha-linolenic acid, (Z,Z)-9,12-octadecadienoic acid, Hexadecanoic acid, Hydrocoumarin, Encecaline-1-(7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone, Senensetin-3,4,5,6,7-pentamethoxy flavone, Beta selinene, Stigmasterol, Beta sitosterol, Quercetin, Quercetin-3-O-rhamnosylglucoside, Linoleic acid, or Conyzorigin can be extracted utilizing a Common Plant Extraction Approach (CPEA). The extraction of compounds can be performed utilizing an ethanol solvent and sterile water solvent and/or ethanol mixed with sterile water (i.e., hydro-alcoholic solvents) separately and the concentrated materials obtained as these solvents systems are pooled together (or maintained separately) in order to obtain an herbal extract for the treatment of BPH.

  本文公开了一种草本提取物及其成分，用于治疗男性良性前列腺增生症和相关衰老症状，并利用龙胆草属植物（包括但不限于Ageratum conyzoides、Ageratum coeruleum和Ageratum houstonianum）的提取物解决男性健康问题。本文公开了至少一种龙舌兰属植物和植物部分的化合物，如，但不限于，Ageratum conyzoides、Ageratum coeruleum 和 Ageratum houstonianum、例如，但不限于，N,N-双（三甲基硅基）-2-苯基-7-（三氟甲基）喹啉-4-胺、3′,4′,5′,6′,7′,8-六甲氧基黄酮、植物醇、前胡烯、叶黄素、角鲨烯、α-亚麻酸、(Z,Z)-9,12-十八碳二烯酸、十六烷酸、氢化香豆素、可利用普通植物提取方法 (CPEA) 提取 Encecaline-1-(7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone, Senensetin-3,4,5,6,7-pentamethoxy flavone, Beta selinene, Stigmasterol, Beta sitosterol, Quercetin, Quercetin-3-O-rhamnosylglucoside, Linoleic acid 或 Conyzorigin。化合物的提取可分别使用乙醇溶剂和无菌水溶剂和/或乙醇与无菌水混合溶剂（即水醇溶剂），然后将这些溶剂系统得到的浓缩物集中在一起（或分别保存），以获得用于治疗良性前列腺增生症的草药提取物。
• Therapeutic agent of osteoporosis comprising an active ingredient of quercetin derivatives
  申请人：——

  公开号：US20020165169A1

  公开（公告）日：2002-11-07

  The present invention relates to a therapeutic agent for osteoporosis which comprises an active ingredient of quercetin derivatives. The quercetin derivatives of the invention can be practically applied for the treatment and prevention of osteoporosis, since they effectively inhibit osteoclast proliferation and stimulate osteoblast proliferation more than conventional therapeutic agents for osteoporosis, and increase trabecular bone area highly without changing hormone level in body and untoward effects on hematopoietic function and immune system.

  本发明涉及一种骨质疏松症治疗剂，其有效成分为槲皮素衍生物。本发明的槲皮素衍生物比传统的骨质疏松症治疗剂更能有效地抑制破骨细胞增殖和刺激成骨细胞增殖，在不改变体内激素水平、不对造血功能和免疫系统产生不良影响的情况下，能显著增加骨小梁面积，因此可实际应用于骨质疏松症的治疗和预防。
• A THERAPEUTIC AGENT OF OSTEOPOROSIS COMPRISING AN ACTIVE INGREDIENT OF QUERCETIN DERIVATIVES
  申请人：Korea Institute of Oriental Medicine

  公开号：EP1309326A1

  公开（公告）日：2003-05-14
• COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING RADIATION-INDUCED BYSTANDER EFFECTS CAUSED BY RADIATION OR RADIOTHERAPY
  申请人：The Regents of the University of Colorado

  公开号：EP3655015A2

  公开（公告）日：2020-05-27
• HERBAL EXTRACT COMPOSITION AND METHOD FOR IMPROVING AND MANAGING BENIGN PROSTATIC HYPERTROPHY (BPH) AND RELATED AGING SYMPTOMS USING EXTRACT FROM AGERATUM SPP
  申请人：GE Nutrients, Inc.

  公开号：EP3813943A1

  公开（公告）日：2021-05-05