花翠素 | 13270-61-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 花翠素
• 英文名称: delphinidin
• 英文别名: 2-(3,4,5-trihydroxyphenyl)chromenylium-3,5,7-triol；delphinidin 3-glucoside；delphynidine；deiphinidin；delphynidin；delfinidin；3,3',4',5,5',7-Hexahydroxyflavylium
• CAS: 13270-61-6
• 化学式: C₁₅H₁₁O₇
• 分子量: 303.248
• InChiKey: JKHRCGUTYDNCLE-UHFFFAOYSA-O

物化性质

• 沸点：
  364.18°C (rough estimate)
• 密度：
  1.3469 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  6
• 氢受体数：
  6

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 花翠素 在 recombinant anthocyanin 5-O-glucosyltransferase 作用下， 以 乙二醇甲醚 为溶剂， 反应 0.27h， 生成
  参考文献：
  名称：

  Ectopic Expression of Anthocyanin 5-O-Glucosyltransferase in Potato Tuber Causes Increased Resistance to Bacteria

  摘要：

  The principal goal of this paper was to investigate the significance of anthocyanin 5-O-glucosyltransferase (5-UGT) for potato tuber metabolism. The ectopic expression of a 5-UGT cDNA in the tuber improved the plant's defense against pathogen infection. The resistance of transgenic lines against Erwinia carotovora subsp. carotovora was about 2-fold higher than for nontransformed plants. In most cases the pathogen resistance was accompanied by a significant increase in tuber yield. To investigate the molecular basis of transgenic potato resistance, metabolic profiling of the plant was performed. In tuber extracts, the anthocyanin 3,5-O-substituted level was significantly increased when compared to that of the control plant. Of six anthocyanin compounds identified, the highest quantity for pelargonidin 3-rutinoside-5-glucoside acylated with p-coumaric acid and peonidin 3-rutinoside-5-glucoside acylated with p-coumaric acid was detected. A significant increase in starch and a decrease in sucrose level in transgenic tubers have been detected. The level of all other metabolites (amino acids, organic acids, polyamines, and fatty acids) was quite the same as in nontransformants. The plant resistance to bacterial infection correlates with anthocyanin content and sucrose level. The properties of recombinant glucosyltransferase were analyzed in in vitro experiments. The enzyme kinetics and its biochemical properties were similar to those from other sources.

  DOI：

  10.1021/jf048449p
• 作为产物：
  描述：

  飞燕草素-3-O-葡萄糖苷 在 三氟乙酸 作用下， 生成 D-葡萄糖 、 花翠素
  参考文献：
  名称：

  Acid Mediated Hydrolysis of Blueberry Anthocyanins.

  摘要：

  使用毛细管区带电泳 (CZE) 研究了酸介导的花青素水解。将市售的野生蓝莓（Bilberry）提取物溶解在不同浓度的TFA（0.1、1、3、9%）中，然后在95℃下进行热分解反应。反应后，通过 CZE 分析样品。通过电泳图中花青素峰模式的变化来确定每种花青素的水解速率和苷元的形成。每个花青素峰以一级动力学方式随时间下降。结果表明，每种花青素的水解率主要由共轭糖的类型决定，而不是由苷元结构决定。花青素水解速率常数的顺序为：阿拉伯糖苷>半乳糖苷>葡萄糖苷，与苷元结构无关。这种花青素水解的动力学行为以及 CZE 迁移率使我们能够将未知的 CZE 峰识别为花翠素 3-O-β-阿拉伯糖苷。在低TFA浓度下，花青素核发生显着分解，但在高TFA浓度下糖苷水解占主导地位。进一步揭示，释放的苷元在较高的TFA条件下连续反应形成聚合产物。

  DOI：

  10.1248/cpb.49.114

文献信息

• Process for synthesising anthocyanidins
  申请人：IDB HOLDING S.p.A.

  公开号：EP0490615A1

  公开（公告）日：1992-06-17

  A process is provided for producing anthocyanidins of formula III wherein m represents an integer from 1 to 3, and X⁻ represents an anion, which involves reducing a protected flavonol of formula where each R⁴ represents a C₁#SB-#₁₀ hydrocarbyl group and m is 1 to 3 and converting OR⁴ groups to hydroxy groups.

  提供了一种制备花青素III的方法 其中m代表从1到3的整数，X⁻代表一个阴离子，涉及将保护的黄酮醇还原为 其中每个R⁴代表一个C₁#SB-#₁₀ 碳氢化合物基团，m为1至3，并将OR⁴基团转化为羟基。
• COMPOSITIONS INCLUDING ANTHOCYANIN OR ANTHOCYANIDIN FOR THE PREVENTION OR TREATMENT OF ARTICULAR CARTILAGE-ASSOCIATED CONDITIONS
  申请人：Johnson Lanny L.

  公开号：US20100196331A1

  公开（公告）日：2010-08-05

  Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the composition includes an anthocyanin or anthocyanidin, glucose, and a pharmaceutically acceptable carrier.

  治疗受试者关节炎关节的方法，包括通过注射将药物组合物给药于关节炎关节，其中该组合物包括花青素或花青素苷、葡萄糖和药用可接受载体。
• STABILIZATION OF HYDROXYLAMINE CONTAINING SOLUTIONS AND METHOD FOR THEIR PREPARATION
  申请人：Lee Wai Mun

  公开号：US20090112024A1

  公开（公告）日：2009-04-30

  The invention relates to the use of amidoximes for prevention of or stabilization of hydroxylamine compounds against undesired decomposition.

  本发明涉及将酰胺肟用于预防或稳定羟基胺化合物，防止其不受控分解。
• New derivatives of resveratrol
  申请人：Mattarei, Andrea

  公开号：EP2774915A1

  公开（公告）日：2014-09-10

  A novel class of derivatives of resveratrol is provided which have favourable physico-chemical properties when compared with resveratrol itself. It is characterized by the presence of three carbamate functions, in which resveratrol is the oxygen-linked moiety, while the nitrogen atom carries a substituent conferring desirable characteristics to the molecule. These new compounds are especially suitable as precursors (prodrugs) and vehicles of resveratrol in preparations used as dietary integrators or in pharmaceutical compositions: they are stable towards oxidative degradation allowing for long shelf lifetimes and have suitable reactivity to regenerate and deliver resveratrol under physiological conditions.

  提供了一类新的白藜芦醇衍生物，与白藜芦醇本身相比，具有有利的理化性质。其特征在于存在三个碳酸酯功能，其中白藜芦醇是氧连接的基团，而氮原子带有赋予分子所需特性的取代基。这些新化合物特别适合作为前药和载体用于作为饮食添加剂或药物组合物中使用的白藜芦醇制剂：它们对氧化降解稳定，允许长的保质期，并在生理条件下具有适当的反应性以再生和输送白藜芦醇。
• [EN] SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING<br/>[FR] COMPOSÉS À PETITES MOLÉCULES POUR FAVORISER UN VIEILLISSEMENT HUMAIN SAIN
  申请人：CARDAX PHARMA INC

  公开号：WO2018183353A1

  公开（公告）日：2018-10-04

  Disclosed herein are methods of activating expression of the FOXO3 gene in a subject comprising administering to a subject small molecule compound (such as astaxanthin and/or one or more astaxanthin derivatives), or pharmaceutically acceptable salts thereof, in an amount sufficient to at least partially increase the amount of FoxO3 expressed in the subject.

  本文揭示了一种激活主体中FOXO3基因表达的方法，包括向主体施用小分子化合物（如虾青素和/或一个或多个虾青素衍生物）或其药用可接受盐，以足够数量至少部分增加主体中表达的FoxO3的方法。