N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-butylamino]propanamide | 1220167-21-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-butylamino]propanamide
• CAS: 1220167-21-4
• 化学式: C₁₄H₃₁N₅O₂
• 分子量: 301.432
• InChiKey: QFMUNDLKYIZNHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-氯吡啶 、 N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-butylamino]propanamide 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.75h， 以51%的产率得到3,3′-(butylazanediyl)bis(N-(2-(di(pyridin-2-yl)amino)ethyl)propanamide)
  参考文献：
  名称：

  基于超支化双吡啶胺配体的镍配合物作为乙烯低聚反应的催化剂前体

  摘要：

  合成了一系列含有双吡啶胺配体的镍配合物，并通过 UV-Vis、FTIR、1H NMR、ESI-MS 和元素分析对其进行了表征。所有用甲基铝氧烷活化的镍配合物都表现出中等的乙烯低聚活性（5.30 × 104 至 2.54 × 105 g/（​​mol·Ni·h）），产生 C4-C18 范围内的低聚物。还研究了反应温度、反应压力、Al/Ni摩尔比和溶剂类型对催化活性和产物选择性的影响。所得产品主要是低碳烯烃（C4和C6）。在优化条件下，相应配体R1=C4H9与NiCl2·6H2O反应形成的R1=C4H9配合物比与R2的配合物表现出更高的催化活性，为2.54×105g/(mol·Ni·h) = C6H13 和 R3 = C6H11 使用甲苯作为溶剂。

  DOI：

  10.1177/1747519819897579
• 作为产物：
  描述：

  methyl 3-butyl (2methyloxycarbonylethyl) aminopropanoate 、 乙二胺 以 甲醇 为溶剂， 反应 168.5h， 生成 N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-butylamino]propanamide
  参考文献：
  名称：

  The design and synthesis of a novel 1,8-naphthalimide PAMAM light-harvesting dendron with fluorescence “off-on” switching core

  摘要：

  A novel polyamidoamine dendron core, peripherally functionalized with 1,8-naphthalimide fluorophores, was configured as a light harvesting antenna in which the system surface was labelled with blue emitting 4-allyloxy-1,8-tiaphtlialimide "donor" dyes capable of both absorbing light and efficiently (96%) transferring the energy to a single, yellow-green emitting 4-N-methylpiperazinyl-1,8-naphthalimide "acceptor" dye. The 1,8-naphthalimide core was designed on the "fluorophore-spacer-receptor" format and was able to function as a fluorescence photoinduced electron transfer sensor. Two different photoinduced electron transfer effects were observed in the new antenna namely that from the receptor to the core fluorophore and that from the polyamidoamine backbone to the peripheral 1,8-naphthalimides. Althogh the core emission intensity of the system was enhanced > four times by reducing the pH from 10 to 2, the fluorescence enhancement of the system in acidic medium, excited within the periphery (lambda(ex) = 360 nm), was approximately twice that of the core fluorescence enhancement after direct excitation of the focal 1,8-naphthalimide (lambda(ex) = 420 nm), because of more efficient energy transfer. The observed "off-on" switching of the core fluorescence over a wid pH scale indicates that the novel light harvesting antenna would be able to act as a highly efficient fluorescent sensor. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2009.09.013

文献信息

• Selective ethylene oligomerization bearing hyperbranched bispyridylamine chromium catalyst
  作者：Jun Wang、Jinyi Liu、Tianyu Lan、Liduo Chen、Libo Wang

  DOI：10.1080/00958972.2019.1587164

  日期：2019.4.3

  ethylene. Effects of reaction temperature, reaction pressure, Al/Cr molar ratio, concentration of catalyst, solvent, and the structure of catalysts on the catalytic activity and product selectivity were investigated. The oligomerization results showed that with increase of reaction temperature, reaction pressure, and Al/Cr molar ratio, the catalytic activity increased and then decreased; the catalytic activity

  摘要 以1.0 G超支化大分子2-氯吡啶、2-氯-4-甲基吡啶和CrCl3(THF)3为原料合成了两种新型超支化双吡啶胺配体和多核铬配合物。超支化配体和铬配合物的结构通过 UV、FT-IR、1H NMR、ESI-MS 和元素分析表征。通过在乙烯低聚反应中使用 MAO 作为活化剂，这些超支化铬配合物被评估为催化剂前体。考察了反应温度、反应压力、Al/Cr摩尔比、催化剂浓度、溶剂和催化剂结构对催化活性和产物选择性的影响。低聚结果表明，随着反应温度、反应压力和Al/Cr摩尔比的增加，催化活性先升高后降低；随着催化剂用量的增加，催化活性不断降低。产品主要以C6和C8为主。在优化条件下，超支化 NNN/Cr(III)/MAO 催化体系的活性为 1.26 × 105 g/(mol·Cr·h)，对 C6 和 C8 的选择性为 63.34%。图形概要
• [EN] BIOREDUCIBLE POLY (B-AMINO ESTER)S FOR SIRNA DELIVERY<br/>[FR] POLY(ESTER B-AMINO) BIORÉDUCTIBLE POUR L'ADMINISTRATION D'ARNSI
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014066811A1

  公开（公告）日：2014-05-01

  Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.

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• Peptide/particle delivery systems
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  公开号：US10786463B2

  公开（公告）日：2020-09-29

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  本发明公开了用于向靶标（如细胞）输送货物（如肽等治疗剂）的聚合物纳米颗粒、微颗粒和凝胶，以及它们在治疗疾病（包括血管生成依赖性疾病，如老年性黄斑变性和癌症）中的用途。 还公开了通过聚合物颗粒和凝胶给药系统配制、稳定和给药单一肽或肽组合的方法。
• PEPTIDE/PARTICLE DELIVERY SYSTEMS
  申请人：Green Jordan Jamieson

  公开号：US20120114759A1

  公开（公告）日：2012-05-10

  Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
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  公开号：US20150273071A1

  公开（公告）日：2015-10-01

  Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.