1-丙硫醇,2-氨基-2-甲基- | 13893-24-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 中文名称: 1-丙硫醇,2-氨基-2-甲基-
• 英文名称: 2-amino-2-methylpropanethiol
• 英文别名: 2-Amino-2-methyl-1-propanethiol；2,2-Dimethyl-2-aminoethanthiol；2-Amino-2-methyl-propan-1-thiol；2-Amino-1-mercapto-2-methyl-propan；2-Amino-2-methyl-propanthiol-(1)；2-amino-2-methyl-propane-1-thiol；2-methyl-2-aminopropanethiol；2-amino-2-methylpropane-1-thiol
• CAS: 13893-24-8
• 化学式: C₄H₁₁NS
• mdl: MFCD19216647
• 分子量: 105.204
• InChiKey: WHFJUXYUXQYZSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丙硫醇,2-氨基-2-甲基- 在 乙醇 、 氯 作用下， 以 四氯化碳 为溶剂， 生成 2-Amino-2-methylpropanesulfonyl Chloride (HCl Salt)
  参考文献：
  名称：

  Synthesis and Properties of β-sultams

  摘要：

  DOI：

  10.1016/s0040-4039(00)81862-6
• 作为产物：
  描述：

  1-溴-2-甲基丙烷-2-胺氢溴酸盐 在 sodium hydrogensulfide 作用下， 以 甲醇 为溶剂， 生成 1-丙硫醇,2-氨基-2-甲基-
  参考文献：
  名称：

  α-氨基酸在2-氨基乙硫醇衍生物的合成中作为潜在的抗辐射剂的用途。

  摘要：

  DOI：

  10.1021/jm00324a027

文献信息

• [EN] GAMMA SECRETASE INHIBITORS<br/>[FR] INHIBITEURS DE LA GAMMA-SECRÉTASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012138678A1

  公开（公告）日：2012-10-11

  Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.

  本文揭示了化合物的结构式（I）及其药用盐，其中每个取代基的定义如规范和索赔中所述。还揭示了含有结构式（I）化合物的药物组合物，以及该化合物在治疗神经退行性疾病或状况如阿尔茨海默病中的用途。
• Nitrogen-containing heterocyclic compounds
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04163844A1

  公开（公告）日：1979-08-07

  Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein Y represents an oxygen atom, a sulfur atom, or a group shown by ##STR2## (wherein m is 1 or 2); n represents 0 or 1; R.sub.1 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a lower alkenyl group; R.sub.2 and R.sub.3, which may be the same or different, each represents a hydrogen atom, a hydroxyl group, a lower alkanoyloxy group, a lower alkyl group or a lower alkenyl group; said R.sub.2 and R.sub.3 may further form together a double bond; R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, an amino group, a lower alkoxy group, a mono or di lower alkylamino group, or a lower alkyl group; said R.sub.5 and R.sub.6 may further form together a lower alkylenedioxy group; and R.sub.7 represents a hydrogen atom, a halogen atom, a lower alkanoyl group, a phenyl group, a phenyl lower alkyl group, a lower alkyl group, a hydroxy lower alkyl group, a di lower alkylamino lower alkyl group, a pyrrolidino lower alkyl group, a piperidino lower alkyl group, a morpholino lower alkyl group, or a 4-lower alkylpiperazino lower alkyl group; (1) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen atom and n is 0, said Y is a group shown by ##STR3## and (2) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are hydrogen atom, at least one of said R.sub.5 and R.sub.6 is the aforesaid group other than hydrogen atom, and n is 0, said Y is oxygen atom or a group shown by ##STR4## and the pharmacologically acceptable non-toxic salts thereof. The compounds are strong analgesic anti-inflammatory agents.

  根据以下公式显示的新型含氮杂环化合物：其中Y代表氧原子、硫原子或由##STR2##所示的基团（其中m为1或2）；n代表0或1；R.sub.1和R.sub.4，可以相同也可以不同，分别代表氢原子、低烷基基团或低烯基基团；R.sub.2和R.sub.3，可以相同也可以不同，分别代表氢原子、羟基基团、低烷酰氧基团、低烷基基团或低烯基基团；所述的R.sub.2和R.sub.3还可以一起形成双键；R.sub.5和R.sub.6，可以相同也可以不同，分别代表氢原子、卤素原子、羟基基团、硝基基团、氨基基团、低烷氧基团、单或双低烷基氨基基团或低烷基基团；所述的R.sub.5和R.sub.6还可以一起形成低烷基二氧基基团；R.sub.7代表氢原子、卤素原子、低烷酰基团、苯基团、苯基低烷基基团、低烷基基团、羟基低烷基基团、双低烷基氨基低烷基基团、吡咯啉基低烷基基团、哌啶基低烷基基团、吗啉基低烷基基团或4-低烷基哌嗪基低烷基基团；（1）当所述的R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6和R.sub.7为氢原子且n为0时，所述的Y是由##STR3##所示的基团；（2）当所述的R.sub.1、R.sub.2、R.sub.3、R.sub.4和R.sub.7为氢原子，至少其中一个所述的R.sub.5和R.sub.6是上述的非氢原子基团，且n为0时，所述的Y是氧原子或由##STR4##所示的基团，以及其药理学上可接受的无毒盐。这些化合物是强效止痛抗炎剂。
• Hydrazinopyridazine compound, process for production thereof, and use
  申请人：Teikoku Hormone Mfg. Co., Ltd.

  公开号：US04599333A1

  公开（公告）日：1986-07-08

  A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.

  一种由以下式表示的联苯二肼吡啶化合物 ##STR1## 其中R.sup.1代表氢原子、卤素原子、羟基、氰基、可能可选择地被卤素原子或羟基取代的较低烷基基团、较低烷氧基、较低烷基硫基、较低烷酰胺基、烯丙氧基或四氢呋喃基氧基、可能可选择地被2-呋喃基、苯基或较低烷氧基取代的较低烷氧基、较低烯基基团、较低烯基氧基或较低炔基基团；R.sup.2代表氢原子、卤素原子、氰基、可能可选择地被卤素原子或较低烷氧基取代的较低烷基基团、较低烷氧基、较低烯基基团或较低烯基氧基；R.sup.3、R.sup.4和R.sup.5，独立地代表氢原子、卤素原子、可能可选择地被较低烷氧基取代的较低烷基基团或较低烷氧基；R.sup.6和R.sup.7，独立地代表氢原子或甲基基团；Y代表--NH.sub.2、--NH--COOC.sub.2 H.sub.5或 ##STR2## Z代表--O--、--S--或 ##STR3## 其中R.sup.8代表氢原子或较低烷基基团；n为1或2，或其盐；一种制备上述化合物的方法；以及将这种化合物用作降压药。
• 1,3-Oxazino(3,2-b)isoquinoline-6-ones
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04329455A1

  公开（公告）日：1982-05-11

  Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein Y represents an oxygen atom, a sulfur atom, or a group shown by ##STR2## (wherein m is 1 or 2); n represents 0 or 1; R.sub.1 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a lower alkenyl group; R.sub.2 and R.sub.3, which may be the same or different, each represents a hydrogen atom, a hydroxyl group, a lower alkanoyloxy group, a lower alkyl group or a lower alkenyl group; said R.sub.2 and R.sub.3 may further form together a double bond; R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, an amino group, a lower alkoxy group, a mono or di lower alkylamino group, or a lower alkyl group; said R.sub.5 and R.sub.6 may further form together a lower alkylenedioxy group; and R.sub.7 represents a hydrogen atom, a halogen atom, a lower alkanoyl group, a phenyl group, a phenyl lower alkyl group, a lower alkyl group, a hydroxy lower alkyl group, a di lower alkylamino lower alkyl group, a pyrrolidino lower alkyl group, a piperidino lower alkyl group, a morpholino lower alkyl group, or a 4-lower alkylpiperazino lower alkyl group; (1) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen atom and n is 0, said Y is a group shown by ##STR3## and (2) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are hydrogen atom, at least one of said R.sub.5 and R.sub.6 is the aforesaid group other than hydrogen atom, and n is 0, said Y is oxygen atom or a group shown by ##STR4## and the pharmacologically acceptable non-toxic salts thereof. The compounds are strong analgesic anti-inflammatory agents.

  该专利涉及一类新型含氮杂环化合物，其化学式为：##STR1## 其中，Y代表一个氧原子，硫原子或者一个表示为##STR2##（其中m为1或2）的基团；n代表0或1；R1和R4，可以相同也可以不同，分别代表氢原子、低碳基或低烯基；R2和R3，可以相同也可以不同，分别代表氢原子、羟基、低烷酰氧基、低碳基或低烯基；R2和R3还可以形成一个双键；R5和R6，可以相同也可以不同，分别代表氢原子、卤素原子、羟基、硝基、氨基、低烷氧基、一或二个低碳基氨基、或低碳基；R5和R6还可以形成一个低碳基亚乙二氧基基团；R7代表一个氢原子、卤素原子、低烷酰基、苯基、苯基低碳基、低碳基、羟基低碳基、二个低碳基氨基低碳基、吡咯烷基低碳基、哌啶基低碳基、吗啉基低碳基、或4-低碳基哌嗪基低碳基；（1）当R1、R2、R3、R4、R5、R6和R7均为氢原子且n为0时，Y为一个表示为##STR3##的基团；（2）当R1、R2、R3、R4和R7均为氢原子，至少其中的R5和R6是上述除氢原子外的基团之一，且n为0时，Y为一个氧原子或一个表示为##STR4##的基团；以及其药学上可接受的无毒盐。这些化合物是强烈的镇痛和抗炎药物。
• Thiazolo[3,2-6]isoquinolines, compositions and use thereof
  申请人：Yamanouchi Pharmaceutical Co. Ltd.

  公开号：US04335129A1

  公开（公告）日：1982-06-15

  Nitrogen containing heterocyclic compounds shown by the formula ##STR1## wherein Y represents an oxygen atom, a sulfur atom, or a group shown by ##STR2## (wherein m is 1 or 2); n represents 0 or 1; R.sub.1 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a lower alkenyl group; R.sub.2 and R.sub.3, which may be the same or different, each represents a hydrogen atom, a hydroxyl groups, a lower alkanoyloxy group, a lower alkyl group or a lower alkenyl group; said R.sub.2 and R.sub.3 may further form together a double bond; R.sub.5 and R.sub.6, which may be the same or different, each represents by hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, an amino group, a lower alkoxy group, a mono or di lower alkylamino group, or a lower alkyl group; said R.sub.5 and R.sub.6 may further form together a lower alkylenedioxy group; and R.sub.7 represents a hydrogen atom, a halogen atom, a lower alkanoyl group, a phenyl group, a phenyl lower alkyl group, a lower alkyl group, a hydroxy lower alkyl group, a di lower alkylamino lower alkyl group, a pyrrolidino lower alkyl group, a piperidino lower alkyl group, a morpholino lower alkyl group, or a 4-lower alkylpiperazino lower alkyl group; (1) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen atom and n is O, said Y is a group shown by ##STR3## and (2) when said R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are hydrogen atom, at least one of said R.sub.5 and R.sub.6 is the aforesaid group other than hydrogen atom, and n is O, said Y is oxygen atom or a group shown by ##STR4## and the pharmacologically acceptable non-toxic salts thereof.

  公式为 ##STR1## 的含氮杂环化合物，其中Y代表氧原子、硫原子或由 ##STR2## 表示的基团（其中m为1或2）；n代表0或1；R.sub.1和R.sub.4，可以相同也可以不同，分别代表氢原子、低碳基或低烯基基团；R.sub.2和R.sub.3，可以相同也可以不同，分别代表氢原子、羟基、低烷酰氧基、低碳基或低烯基基团；R.sub.2和R.sub.3还可以形成双键；R.sub.5和R.sub.6，可以相同也可以不同，分别代表氢原子、卤素原子、羟基、硝基、氨基、低烷氧基、一或二个低碳基氨基基团或低碳基基团；R.sub.5和R.sub.6还可以形成低碳基亚乙氧基基团；R.sub.7代表氢原子、卤素原子、低烷酰基、苯基、苯基低碳基、低碳基、羟基低碳基、二个低碳基氨基低碳基、吡咯烷基低碳基、哌啶烷基低碳基、吗啉烷基低碳基或4-低碳基哌嗪基低碳基；（1）当R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6和R.sub.7均为氢原子且n为O时，Y为由 ##STR3## 表示的基团；（2）当R.sub.1、R.sub.2、R.sub.3、R.sub.4和R.sub.7均为氢原子，至少有一个R.sub.5和R.sub.6为上述氢原子以外的基团，且n为O时，Y为氧原子或由 ##STR4## 表示的基团；以及其药理学上可接受的非毒性盐。