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4-(morpholin-4-yl)-2-(trifluoromethoxy)benzaldehyde | 1446819-04-0

中文名称
——
中文别名
——
英文名称
4-(morpholin-4-yl)-2-(trifluoromethoxy)benzaldehyde
英文别名
4-Morpholino-2-(trifluoromethoxy)benzaldehyde;4-morpholin-4-yl-2-(trifluoromethoxy)benzaldehyde
4-(morpholin-4-yl)-2-(trifluoromethoxy)benzaldehyde化学式
CAS
1446819-04-0
化学式
C12H12F3NO3
mdl
——
分子量
275.227
InChiKey
NXICLGMIPAQPCI-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    381.5±42.0 °C(Predicted)
  • 密度:
    1.343±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.3
  • 重原子数:
    19
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.42
  • 拓扑面积:
    38.8
  • 氢给体数:
    0
  • 氢受体数:
    7

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • [EN] PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF<br/>[FR] COMPOSÉS DE PYRROLO-PYRROLE CARBAMATE ET COMPOSÉS ORGANIQUES ASSOCIÉS, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS MÉDICALES
    申请人:ABIDE THERAPEUTICS INC
    公开号:WO2015003002A1
    公开(公告)日:2015-01-08
    The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, Ν,Ν-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
    这项发明提供了吡咯-吡咯氨基甲酸酯及相关有机化合物,含有这些化合物的组合物,医疗工具包,以及使用这些化合物和组合物治疗患者的方法,例如固体肿瘤癌症、肥胖症、唐氏综合征、阿尔茨海默病或疼痛。八氢吡咯-吡咯氨基甲酸酯可以由六氟异丙醇、Ν,Ν-二琥珀酰亚胺等物质衍生而来。此外还描述了氨基甲酸酯在MAGL、FAAH和ABHD6测定中的活性。
  • CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME
    申请人:ABIDE THERAPEUTICS, INC
    公开号:US20150018335A1
    公开(公告)日:2015-01-15
    This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    本公开提供了化合物和组合物,这些化合物和组合物可能是MAGL和/或ABHD6的调节剂,并且可用作药物制剂,包括披露的化合物作为至少一个活性剂的制药组合物的制备过程。本公开还提供了治疗患有疼痛、实体肿瘤癌和/或肥胖等症状的患者的方法,包括给患者投与披露的化合物或组合物。
  • Carbamate compounds and of making and using same
    申请人:Abide Therapeutics, Inc.
    公开号:US09133148B2
    公开(公告)日:2015-09-15
    This disclosure provides piperazine carbamates and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed piperazine carbamates as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    本披露提供了哌嗪氨基甲酸酯和组合物,可以调节MAGL和/或ABHD6,并将其用作药物,以及其制备过程和包括披露的哌嗪氨基甲酸酯作为至少一种活性剂的制药组合物。该披露还提供了一种治疗患有疼痛,实体肿瘤癌和/或肥胖等症状的患者的方法,包括给予披露的化合物或组合物。
  • PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
    申请人:ABIDE THERAPEUTICS, INC.
    公开号:US20160137649A1
    公开(公告)日:2016-05-19
    The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
    该发明提供了吡咯-吡咯氨基甲酸酯及其相关有机化合物,含有这些化合物的组合物,医疗用品以及使用这些化合物和组合物治疗患者的医疗疾病的方法,例如实体瘤癌,肥胖症,唐氏综合症,阿尔茨海默病或疼痛。八氢吡咯-吡咯氨基甲酸酯可以由六氟异丙醇,N,N-二琥珀酰亚胺等制得。此外还描述了氨基甲酸酯在MAGL,FAAH和ABHD6测定中的活性。
  • CARBAMATE COMPOUNDS FOR USE IN THERAPY
    申请人:Lundbeck La Jolla Research Center, Inc.
    公开号:EP3698782A1
    公开(公告)日:2020-08-26
    This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compunds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    本公开提供了可作为MAGL和/或ABHD6调节剂的化合物和组合物及其作为药剂的用途、制备工艺,以及包括所公开的组合物作为至少一种活性剂的药物组合物。本公开还提供了治疗有需要的患者的方法,其中患者患有疼痛、实体瘤癌症和/或肥胖症等适应症,包括施用公开的化合物或组合物。
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