1-[氨基(苯基)甲基]-2-萘酚盐酸盐 | 481-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-[氨基(苯基)甲基]-2-萘酚盐酸盐
• 英文名称: d-[α-(2-Oxy-naphthyl-(1))-benzylamin]
• 英文别名: 1-(alpha-Aminobenzyl)-2-naphthol；1-[amino(phenyl)methyl]naphthalen-2-ol
• CAS: 481-82-3
• 化学式: C₁₇H₁₅NO
• mdl: MFCD00663201
• 分子量: 249.312
• InChiKey: PZMIGEOOGFFCNT-UHFFFAOYSA-N

物化性质

• 熔点：
  173-175 °C(Solv: ethanol (64-17-5))
• 沸点：
  451.1±30.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.058
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[氨基(苯基)甲基]-2-萘酚盐酸盐 、 4-甲氧基苯甲醛 生成
  参考文献：
  名称：

  DESAI, N. C.;SHUKLA, H. K.;LANGALIA, N. A.;THAKER, K. A., J. INDIAN CHEM SOC., 1984, 61, N 8, 711-713

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸 、 N-[(2-hydroxy-[1]naphthyl)-phenyl-methyl]-glucopyranosylamine 生成 葡萄糖 、 1-[氨基(苯基)甲基]-2-萘酚盐酸盐
  参考文献：
  名称：

  Betti, Gazzetta Chimica Italiana, 1906, vol. 36 II, p. 669

  摘要：

  DOI：

文献信息

• SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US20180362439A1

  公开（公告）日：2018-12-20

  The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

  本发明涉及一种萨库比曲中间体及其制备方法。本文披露的萨库比曲中间体可通过一种化合物的去保护反应制备。此外，该中间体可用作合成萨库比曲的原料。本文披露的方法具有易获得的原料、简单的制备过程、低成本、环保等优点，非常适合工业生产。
• Processes for the Preparation of Tasimelteon and Intermediates Thereof
  申请人：Apotex Inc.

  公开号：US20170355688A1

  公开（公告）日：2017-12-14

  The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1).

  本发明提供了制备Tasimelteon（1）的工艺，以及制备用于制备Tasimelteon（1）的中间体Formula（2）、（3）和（4）的工艺。
• [EN] NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE N-[2-[(1S)-1-(3-ÉTHOXY-4-MÉTHOXYPHÉNYL)-2-(MÉTHYLSULFONYL)ÉTHYL]-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACÉTAMIDE
  申请人：UNICHEM LAB LTD

  公开号：WO2018203192A1

  公开（公告）日：2018-11-08

  An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios.

  提供了一种用于制备Apremilast（Formula I）和Apremilast form B或其药用可接受盐的替代和改进的过程。这种新的过程包括在丙酮中进行氢化，随后在甲基异丁基酮（MIBK）和乙酸混合物中以特定体积比进行环化和乙酰化，然后进行缩合。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• Sacubitril intermediate and preparation method thereof
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US10479753B2

  公开（公告）日：2019-11-19

  The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

  本发明涉及一种sacubitril中间体及其制备方法。本发明公开的sacubitril中间体可通过化合物的脱保护反应制备。此外，该中间体还可用作合成 sacubitril 的原料。本发明公开的方法具有原料易得、制备工艺简单、成本低、环境友好等优点，非常适合工业化生产。