1-[α-(4-methoxy-benzylidenamino)-benzyl]-[2]naphthol | 97035-64-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[α-(4-methoxy-benzylidenamino)-benzyl]-[2]naphthol
• 英文别名: 1-[[(4-Methoxyphenyl)methylideneamino]-phenylmethyl]naphthalen-2-ol
• CAS: 97035-64-8
• 化学式: C₂₅H₂₁NO₂
• 分子量: 367.447
• InChiKey: HUIQEPMQCKTSJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[α-(4-methoxy-benzylidenamino)-benzyl]-[2]naphthol 在 碘苯二乙酸 作用下， 以 甲醇 为溶剂， 以75%的产率得到3-(4-methoxyphenyl)-1-phenyl-1H-benzo[f][1,3]benzoxazine
  参考文献：
  名称：

  Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines

  摘要：

  A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well as for antifungal activity. The compounds 3c, 3e, 7a, 7d and 7k showed significant antibacterial activity and 71 showed moderate antifungal activity. The cytotoxicity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines showed that 3e and 7e are more effective against breast, lung and colon cell proliferation. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.018
• 作为产物：
  描述：

  N-亚苄基-(2-羟基-1-萘)苄胺 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 生成 1-[α-(4-methoxy-benzylidenamino)-benzyl]-[2]naphthol
  参考文献：
  名称：

  Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines

  摘要：

  A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well as for antifungal activity. The compounds 3c, 3e, 7a, 7d and 7k showed significant antibacterial activity and 71 showed moderate antifungal activity. The cytotoxicity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines showed that 3e and 7e are more effective against breast, lung and colon cell proliferation. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.018

文献信息

• Impact of the initial doses of rocuronium and pancuronium on subsequent maintenance for neuromuscular block
  作者：Steven E. Kern、Robert J. Fragen、Paul C. Fitzgerald、Michiel van Zeeland、Joel O. Johnson

  DOI：10.1007/bf03019724

  日期：2001.2

  Purpose: To determine the impact of the neuromuscular blocking agent given for intubation on the duration of effect of multiple maintenance doses of pancuronium and rocuronium.Methods: Seventy-eight subjects were randomly assigned to receive one of four dosing combinations for intubation and neuromuscular maintenance: rocuronium for intubation and maintenance, rocuronium for intubation and pancuronium for maintenance, pancuronium for intubation and rocuronium for maintenance, or pancuronium for both. Each time that the first twitch response returned to 25% of the baseline value, the duration of the dose was determined and another maintenance dose was administered. The duration of action of the maintenance doses was compared between the groups.Results: Twitch suppression from the first maintenance dose was shorter for subjects who received rocuronium for both doses (Group RR) compared with that for subjects that received pancuronium (Groups PR & PP) as their intubation dose ( 17.6 vs 34 & 59.8 min, respectively, P < 0.05). Subjects who received rocuronium followed by pancuronium (Group RP) showed a shorter duration of twitch suppression after the first maintenance dose than the group that received pancuronium for both doses (Group PP) (21.3 vs 59.8 min, P < 0.05). By the third maintenance dose. the influence of the intubating dose on the maintenance dose duration had essentially diminished.Conclusions: For combinations of rocuronium and pancuronium, the duration of twitch suppression after a maintenance dose is only dependent on the first agent given for the first two maintenance doses administered.
• Desai, N.C.; Shukla, H.K.; Langalia, N.A., Journal of the Indian Chemical Society, 1984, vol. 61, p. 711 - 713
  作者：Desai, N.C.、Shukla, H.K.、Langalia, N.A.、Thaker, K.A.

  DOI：——

  日期：——
• Betti, Gazzetta Chimica Italiana, 1907, vol. 37 I, p. 63,64
  作者：Betti

  DOI：——

  日期：——
• Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines
  作者：Vikas Verma、Kuldeep Singh、Devinder Kumar、Thomas M. Klapötke、Jörg Stierstorfer、Balasubramanian Narasimhan、Asif Khurshid Qazi、Abid Hamid、Sundeep Jaglan

  DOI：10.1016/j.ejmech.2012.08.018

  日期：2012.10

  A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well as for antifungal activity. The compounds 3c, 3e, 7a, 7d and 7k showed significant antibacterial activity and 71 showed moderate antifungal activity. The cytotoxicity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines showed that 3e and 7e are more effective against breast, lung and colon cell proliferation. (C) 2012 Elsevier Masson SAS. All rights reserved.