galactitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: galactitol
• 英文别名: (3S,4R,5S)-hexane-1,2,3,4,5,6-hexol
• 化学式: C₆H₁₄O₆
• 分子量: 182.174
• InChiKey: FBPFZTCFMRRESA-CEZCPVKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  galactitol 在 manganese(III) pyrophosphate 、 硫酸 作用下， 以 水 为溶剂， 生成 galactose
  参考文献：
  名称：

  Kinetics of reactions of manganese(III) pyrophosphate with some hexitols

  摘要：

  DOI：

  10.1016/0008-6215(83)88273-1

文献信息

• NOVEL ANTHRACYCLINE DERIVATIVES CONTAINING TRIFLUOROMETHYLATED SUGAR UNIT
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0749976A1

  公开（公告）日：1996-12-27

  Novel anthracycline derivatives have now been produced, which exhibit higher antitumor activities and lower toxicities than those of daunomycin, adriamycin etc. that have been clinically used as anticancer agents. That is, a daunomycinone or adriamycinone derivative represented by the general formula (I): wherein R is a hydrogen atom or a hydroxyl group, and 7-O-(2,6-dideoxy-6,6,6-trifluoro-α-L-lyxo-hexopyranosyl)adriamycinone derivative which is an adriamycinone derivative represented by formula (II): have now been newly synthesized. The novel anthracycline derivatives having the general formula (I) and formula (II), respectively, show excellent anticancer or antitumor activities and are of low toxicities. These novel compounds are very useful as anticancer or antitumor agents and are expected to be useful for the therapeutic treatments of a variety of cancers and tumors, similarly to daunomycin or adriamycin.

  目前已生产出新型蒽环类衍生物，与临床上用作抗癌剂的达霉素、阿霉素等相比，它们具有更高的抗肿瘤活性和更低的毒性。即由通式（I）代表的达霉素酮或阿霉素酮衍生物： 其中 R 是氢原子或羟基，7-O-(2,6-二脱氧-6,6,6-三氟-α-L-来苏己吡喃糖基)阿霉素酮衍生物是由式（II）表示的阿霉素酮衍生物： 的阿霉素衍生物。 分别具有通式(I)和式(II)的新型蒽环类衍生物显示出卓越的抗癌或抗肿瘤活性，而且毒性低。这些新型化合物作为抗癌剂或抗肿瘤剂非常有用，有望与达霉素或阿霉素类似，用于各种癌症和肿瘤的治疗。
• Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0761678A1

  公开（公告）日：1997-03-12

  To provide novel fluorine-containing anthracycline derivatives having high antitumor activities and a solubility in water, there have now been synthesized a 7-O-(2,6-dideoxy-2-fluoro-3-O- or -4-O- or -3,4-di-O-aminoalkanoyl-α-L-talopyranosyl)daunomycinone or -adriamycinone of general formula (I) shown below, as well as a 7-O-(3-O- or -4-O-or -3,4-di-O-aminoalkanoyl-2,6-dideoxy-2,6,6,6-tetrafluoro-α-L-talopyranosyl- or -2,6-dideoxy-6,6,6-trifluoro-α-L-lyxo-hexopyranosyl)adriamycinone of general formula (II) shown below:- wherein either one or both of A1 and A2 is or are an α-amino acid residue or an ω-amino acid residue and T denotes a fluorine or hydrogen atom. The novel fluorine-containing anthracycline derivatives of general formulae (I) and (II) are highly active against tumors and soluble in water, and they are useful as antitumor agents administrable in the form of injectable solution.

  为了提供具有高抗肿瘤活性和水溶性的新型含氟蒽环类衍生物，现已合成了通式(I)如下的7-O-(2,6-二脱氧-2-氟-3-O-或-4-O-或-3,4-二-O-氨基烷酰基-α-L-吡喃甘露糖基)daunomycinone或-adriamycinone、以及下表所示通式(II)的 7-O-(3-O-或-4-O-或-3,4-二-O-氨基烷酰基-2,6-二脱氧-2,6,6,6-四氟-α-L-吡喃他酰胺基-或-2,6-二脱氧-6,6,6-三氟-α-L-来苏己吡喃糖基)阿霉素酮：- 其中 A1 和 A2 中的一个或两个是 α-氨基酸残基或 ω-氨基酸残基，T 表示氟原子或氢原子。通式(I)和(II)的新型含氟蒽环类衍生物具有很强的抗肿瘤活性，可溶于水，可作为抗肿瘤药物以注射液的形式给药。
• ANTHRACYCLINE DERIVATIVES CONTAINING TRIFLUOROMETHYLATED SUGAR UNIT
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0749976B1

  公开（公告）日：1999-04-28
• US5719130A
  申请人：——

  公开号：US5719130A

  公开（公告）日：1998-02-17
• US5789386A
  申请人：——

  公开号：US5789386A

  公开（公告）日：1998-08-04