d-glucuronate | 2002-48-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: d-glucuronate
• 英文别名: aldehydo-D-glucuronate；(2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate
• CAS: 2002-48-4
• 化学式: C₆H₉O₇
• 分子量: 193.133
• InChiKey: IAJILQKETJEXLJ-QTBDOELSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-glutamate salt 、 d-glucuronate 以 水 为溶剂， 生成 (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine glucuronate salt
  参考文献：
  名称：

  SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS

  摘要：

  8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并哌啶的盐与手性有机酸结合，以及包含它们的药物组合物，可用于体重管理等方面。

  公开号：

  US20160151381A1
• 作为产物：
  描述：

  D-glucuronate 生成 d-glucuronate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• New polyacetylene glucosides from the florets of Carthamus tinctorius and their weak anti-inflammatory activities
  作者：Jun He、Yi Shen、Jian-Shuang Jiang、Ya-Nan Yang、Zi-Ming Feng、Pei-Cheng Zhang、Shao-Peng Yuan、Qi Hou

  DOI：10.1016/j.carres.2011.06.015

  日期：2011.9

  Eight new linear polyacetylene glucosides (1-8), containing two C(10)-, one C(13)- and five C(14)-acetylenes, together with three known polyacetylenes (9-11) were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3-9 were confirmed by Snatzke and Gerards's method, observing

  从小花的小花中分离出八个新的线性聚乙炔葡糖苷（1-8），含两个C（10）-，一个C（13）-和五个C（14）-乙炔，以及三个已知的聚乙炔（9-11）。 Carthamus tinctorius L.通过光谱学方法和化学证据阐明了它们的结构。化合物3-9的绝对构型已通过Snatzke和Gerards的方法得到证实，观察到在CHCl（3）中加入四（三氟乙酸）二铑（Rh（2）（OCOCF（3））（4）]后诱导的圆二色性。还测试了所有分离的化合物（1-11）对小鼠巨噬细胞中LPS诱导的NO产生的抑制活性，并且在1×10（-5）M的浓度下仅表现出弱的活性。
• Process for making morphine-6-glucuronide or substituted
  申请人：Salford Ultrafine Chemicals and Research Limited

  公开号：US05621087A1

  公开（公告）日：1997-04-15

  ##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.

  ##STR1## 公式(I)的吗啡-6-葡萄糖醛酸酯或取代了的吗啡-6-葡萄糖醛酸酯是通过在路易斯酸催化剂的存在下，在没有银催化剂、氢氧化钡和其他重金属衍生物的情况下，将葡萄糖酸酯和/或取代了的葡萄糖酸酯与吗啡或取代了的吗啡结合而制成的。
• Myo-inositol oxygenases
  申请人：——

  公开号：US20040185562A1

  公开（公告）日：2004-09-23

  The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid, and glucaric acid.

  该发明提供了与有机产品（如葡萄糖醛酸，抗坏血酸和葡萄糖酸）生产相关的方法和材料。具体地，该发明提供了细胞、细胞培养方法、分离核酸分子以及生产各种有机产品（如葡萄糖醛酸、抗坏血酸和葡萄糖酸）的方法和材料。
• Salts of lorcaserin with optically active acids
  申请人：Blackburn Anthony C.

  公开号：US09248133B2

  公开（公告）日：2016-02-02

  Salts of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine with optically active acids, and pharmaceutical compositions comprising them that are useful for, inter alia, weight management.

  含有手性酸的8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并嗪盐，以及包含它们的药物组合物，可用于体重管理等用途。
• In vivo role of aldehyde reductase
  作者：Motoko Takahashi、Satoshi Miyata、Junichi Fujii、Yoko Inai、Shigemitsu Ueyama、Motoko Araki、Tomoyoshi Soga、Reiko Fujinawa、Chiaki Nishitani、Shigeru Ariki、Takeyuki Shimizu、Tomomi Abe、Yoshito Ihara、Morimitsu Nishikimi、Yasunori Kozutsumi、Naoyuki Taniguchi、Yoshio Kuroki

  DOI：10.1016/j.bbagen.2012.07.003

  日期：2012.11

  Background: Aldehyde reductase (AKR1A; EC 1.1.1.2) catalyzes the reduction of various types of aldehydes. To ascertain the physiological role of AKR1A, we examined AKR1A knockout mice.Methods: Ascorbic acid concentrations in AKR1A knockout mice tissues were examined, and the effects of human AKR1A transgene were analyzed. We purified AKR1A and studied the activities of glucuronate reductase and glucuronolactone reductase, which are involved in ascorbic acid biosynthesis. Metabolomic analysis and DNA microarray analysis were performed for a comprehensive study of AKR1A knockout mice.Results: The levels of ascorbic acid in tissues of AKR1A knockout mice were significantly decreased which were completely restored by human AKR1A transgene. The activities of glucuronate reductase and glucuronolactone reductase, which are involved in ascorbic acid biosynthesis, were suppressed in AKR1A knockout mice. The accumulation of D-glucuronic acid and saccharate in knockout mice tissue and the expression of acute-phase proteins such as serum amyloid A2 are significantly increased in knockout mice liver.Conclusions: AKR1A plays a predominant role in the reduction of both D-glucuronic acid and D-glucurono-gamma-lactone in vivo. The knockout of AKR1A in mice results in accumulation of D-glucuronic acid and saccharate as well as a deficiency of ascorbic acid, and also leads to upregulation of acute phase proteins.General significance: AKR1A is a major enzyme that catalyzes the reduction of D-glucuronic acid and D-glucurono-gamma-lactone in vivo, besides acting as an aldehyde-detoxification enzyme. Suppression of AKR1A by inhibitors, which are used to prevent diabetic complications, may lead to the accumulation of D-glucuronic acid and saccharate. (C) 2012 Elsevier B.V. All rights reserved.