N-(carbobenzyloxy)-β-benzyl-L-aspartyl-D-valine | 154653-24-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(carbobenzyloxy)-β-benzyl-L-aspartyl-D-valine
• CAS: 154653-24-4
• 化学式: C₂₄H₂₈N₂O₇
• 分子量: 456.496
• InChiKey: PRRWZJLYFOKKGG-PZJWPPBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.64
• 重原子数：
  33.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  131.03
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-(carbobenzyloxy)-β-benzyl-L-aspartyl-D-valine 在 palladium on activated charcoal N-羟基-5-降冰片烯-2,3-二甲酰亚胺 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 25.0 ℃ 、275.79 kPa 条件下， 反应 3.0h， 生成 L-aspartyl-D-valine (S)-α-ethylbenzylamide
  参考文献：
  名称：

  Discovery and Synthesis of a New Series of High-Potency L-Aspartyl-D-.alpha.-aminoalkanoyl-(S)-.alpha.-alkylbenzylamide Sweeteners

  摘要：

  A new series of L-aspartyl-D-amino acid amide sweeteners is described in which the amide portion is prepared from an cl-alkyl-substituted benzylamine. These materials show good taste characteristics and are 5 times more stable than aspartame at typical beverage pH (3-4). The most potent member of the series is L-aspartyl-D-alpha-aminobutyric acid (S)-alpha-ethylbenzylamide, having a sweetness potency 2000 times that of a 10% sucrose solution.

  DOI：

  10.1021/jf00056a003
• 作为产物：
  描述：

  CBZ-L-天门冬氨酸β-苄酯 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 生成 N-(carbobenzyloxy)-β-benzyl-L-aspartyl-D-valine
  参考文献：
  名称：

  Discovery and Synthesis of a New Series of High-Potency L-Aspartyl-D-.alpha.-aminoalkanoyl-(S)-.alpha.-alkylbenzylamide Sweeteners

  摘要：

  A new series of L-aspartyl-D-amino acid amide sweeteners is described in which the amide portion is prepared from an cl-alkyl-substituted benzylamine. These materials show good taste characteristics and are 5 times more stable than aspartame at typical beverage pH (3-4). The most potent member of the series is L-aspartyl-D-alpha-aminobutyric acid (S)-alpha-ethylbenzylamide, having a sweetness potency 2000 times that of a 10% sucrose solution.

  DOI：

  10.1021/jf00056a003