N-<2-(2-Hydroxyethoxy)ethyl>-1-(4-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetamid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-<2-(2-Hydroxyethoxy)ethyl>-1-(4-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetamid
• 英文别名: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[2-(2-hydroxyethoxy)ethyl]acetamide
• 化学式: C₂₃H₂₅ClN₂O₅
• 分子量: 444.915
• InChiKey: YZJWGJGLDGAQGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吲哚美辛 在 氯化亚砜 作用下， 以 1,2-二氯乙烷 、 苯 为溶剂， 反应 1.0h， 生成 N-<2-(2-Hydroxyethoxy)ethyl>-1-(4-chlorbenzoyl)-5-methoxy-2-methylindol-3-acetamid
  参考文献：
  名称：

  Boltze; Brendler; Jacobi, Arzneimittel-Forschung/Drug Research, 1980, vol. 30, # 8 A, p. 1314 - 1325

  摘要：

  DOI：

文献信息

• BOLTZE K.-H.; BRENDLER O.; JACOBI H.; OPITZ W.; RADDATZ S.; SEIDEL P.-R.;+, ARZNEIMITTEL-FORSCH., 1980, 30, NO 8A, 2314-2325
  作者：BOLTZE K.-H.、 BRENDLER O.、 JACOBI H.、 OPITZ W.、 RADDATZ S.、 SEIDEL P.-R.、+

  DOI：——

  日期：——
• Novel Glp-1 Derivatives
  申请人：Lau Jesper

  公开号：US20070203058A1

  公开（公告）日：2007-08-30

  Novel polypeptide derivatives having protracted profile of action. The present invention relates to a compound which comprises a therapeutic polypeptide linked to an albumin binding residue via a hydrophilic spacer. The present invention also relates to a compound which comprises a therapeutic polypeptide linked to an albumin binding residue via a hydrophilic spacer that separates the polypeptide and the albumin binding residue with a chemical moiety comprising at least 5 non-hydrogen atoms where 30-50% of these atoms are either N or O. In one embodiment of this invention the spacer is defined as —(CH 2 ) l D[(CH 2 ) n E] m (CH 2 ) p Q q -, wherein l, m and n independently are 1-20 and p is 0-10, Q is -Z-(CH 2 ) l D[(CH 2 ) n G] m (CH 2 ) p —, q is an integer in the range from 0 to 5, each D, E and G independently are selected from —O—, NR 3 —, —N(COR 4 )—, —PR 5 (O)—, and —P(OR 6 )(O)—, wherein R 3 , R 4 , R 5 , and R 6 independently represent hydrogen or C 1-6 -alky, Z is selected from —C(O)NH—, —C(O)NHCH 2 —, —OC(O)NH—, —C(O)NHCH 2 CH 2 —, —C(O)CH 2 —, —C(O)CH═CH—, —(CH 2 ) s —, —C(O)—, —C(O)O— or —NHC(O)—, wherein s is 0 or 1.
• Boltze; Brendler; Jacobi, Arzneimittel-Forschung/Drug Research, 1980, vol. 30, # 8 A, p. 1314 - 1325
  作者：Boltze、Brendler、Jacobi、Opitz、Raddatz、Seidel、Vollbrecht

  DOI：——

  日期：——