2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester | 1312606-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester
• 英文别名: 2-{1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid 1-adamantyl ester；1-adamantyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
• CAS: 1312606-88-4
• 化学式: C₂₉H₃₀ClNO₄
• 分子量: 492.014
• InChiKey: INWZAKHMWREXBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-金刚烷醇 、 吲哚美辛 在 双(2-氧代-3-恶唑烷基)次磷酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.17h， 以55%的产率得到2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester
  参考文献：
  名称：

  Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors

  摘要：

  Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their pharmacological activities by inhibiting cyclooxygenase (COX)-1 and COX-2. Previous studies have shown that esters and amides of nonselective inhibitors such as indomethacin are selective against COX-2, which is the therapeutically relevant isoform. Structure-activity analysis indicates that substituted phenyl rings are tolerated as ester components. In the present study, the introduction of inorganic ortho-and meta-carbaborane moieties was explored with the aim to create COX-2 inhibitors and more importantly to investigate the validity of using these boron clusters as drug entities. Interestingly, only the ortho-carbaborane ester was active whereas the meta isomer was not. A similar lack of inhibitory potency was observed when an adamantyl substituent or alkylene spacers at the carbaborane were introduced in the ester functionality. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.03.054

文献信息

• Borane-Catalyzed C(sp³)–F Bond Arylation and Esterification Enabled by Transborylation
  作者：Dominic R. Willcox、Gary S. Nichol、Stephen P. Thomas

  DOI：10.1021/acscatal.1c00282

  日期：2021.3.19

  given the high thermodynamic barrier to C–F bond cleavage. Stoichiometric hydridoborane-mediated C–F functionalization has recently emerged, but is yet to be rendered catalytic. Herein, the borane-catalyzed coupling of alkyl fluorides with arenes (carbon–carbon bond formation) and carboxylic acids (carbon–oxygen bond formation) has been developed using transborylation reactions to achieve catalytic

  鉴于氟碳键断裂的高热力学障碍，碳氟键的活化和功能化是一个重大的合成挑战。化学计量氢化硼硼烷介导的CF功能化最近出现，但尚未被催化。在本文中，已经开发出了硼烷催化的烷基氟与芳烃（形成碳-碳键）和羧酸（形成碳-氧键）的偶联反应，以实现催化转化。在各种结构上和电子分化芳烃和羧酸的使用9-硼杂双环[3.3.1]壬烷（H-达到成功的C-C和C-O耦合乙-9-BBN）作为催化剂和频哪醇硼烷（HBpin），具有宽泛的官能团耐受性。实验和计算研究表明碳-碳和碳-氧偶联反应的机理二分法。乙-F transborylation（B-F / B-H复分解）F-之间乙-9-BBN和HBpin启用碳-碳键形成的催化周转，而烷基氟化物和acyloxyboronic酯之间的直接交换（C-F / B -O复分解）被提议用于碳-氧偶联，其中H - B -9-BBN催化羧酸与HBpin的脱氢偶联。
• Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors
  作者：Matthias Scholz、Anna L. Blobaum、Lawrence J. Marnett、Evamarie Hey-Hawkins

  DOI：10.1016/j.bmc.2011.03.054

  日期：2011.5

  Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their pharmacological activities by inhibiting cyclooxygenase (COX)-1 and COX-2. Previous studies have shown that esters and amides of nonselective inhibitors such as indomethacin are selective against COX-2, which is the therapeutically relevant isoform. Structure-activity analysis indicates that substituted phenyl rings are tolerated as ester components. In the present study, the introduction of inorganic ortho-and meta-carbaborane moieties was explored with the aim to create COX-2 inhibitors and more importantly to investigate the validity of using these boron clusters as drug entities. Interestingly, only the ortho-carbaborane ester was active whereas the meta isomer was not. A similar lack of inhibitory potency was observed when an adamantyl substituent or alkylene spacers at the carbaborane were introduced in the ester functionality. (C) 2011 Elsevier Ltd. All rights reserved.