Synthesis and hydrolytic stability of cyclic phosphatidic acids: implications for synthetic- and proto-cell studies
作者:Veronica Egas Ortuno、Sunil Pulletikurti、Kollery S. Veena、Ramanarayanan Krishnamurthy
DOI:10.1039/d2cc00292b
日期:——
Cyclic phosphatidic acids (cPAs) are bioactive compounds with therapuetic potential, but are in short supply. We describe a robust synthesis of cPAs employing an efficient cyclophosphorylation procedure and report on their hydrolytic properties – which should facilitate the study of their biological properties and as plausible proto- and synthetic-cell components.
Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots
作者:Woo Song Lee、Mi Jeong Kim、Young-Il Beck、Yong-Dae Park、Tae-Sook Jeong
DOI:10.1016/j.bmcl.2005.05.056
日期:2005.8
(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA2 inhibitory activities with IC50 values of 45.0 and 52.0 mu M, respectively. (c) 2005 Elsevier Ltd. All rights reserved.