γ-diphenylphosphinopropyl alcohol | 2360-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: γ-diphenylphosphinopropyl alcohol
• 英文别名: 3-hydroxypropyldiphenylphosphine；3-diphenylphosphino-1-propanol；diphenylphosphino-3 propanol-1；diphenylphosphinopropanol；3-diphenylphosphanyl-propan-1-ol；<3-Hydroxy-propyl>-diphenyl-phosphin；1-Propanol, 3-(diphenylphosphino)-；3-diphenylphosphanylpropan-1-ol
• CAS: 2360-09-0
• 化学式: C₁₅H₁₇OP
• 分子量: 244.273
• InChiKey: WJSIEWJPUZANTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  γ-diphenylphosphinopropyl alcohol 在 双氧水 作用下， 以 丙酮 为溶剂， 以97%的产率得到3-(diphenylphosphinoyl)-1-propanol
  参考文献：
  名称：

  Hydrogen bond in some phosphorus-substituted aliphatic alcohols

  摘要：

  DOI：

  10.1007/bf00951885
• 作为产物：
  描述：

  1-(3-(diphenylphosphaneyl)propoxy)-2,2,6,6-tetramethylpiperidine 在 溶剂黄146 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 γ-diphenylphosphinopropyl alcohol
  参考文献：
  名称：

  N-（酰氧基）邻苯二甲酰亚胺对Ru-光催化还原脂肪族羧酸的脱羧氧化作用

  摘要：

  报道了在钌光氧化还原催化下，脂肪族羧酸衍生物与（2,2,6,6-四甲基哌啶-1-基）氧基（TEMPO）的脱羧氨氧基化反应。关键的转变需要使用Hantzsch酯作为还原剂进行高效的光氧化还原催化循环。随后的烷氧基胺可以很容易地在一个罐中转化为相应的醇，代表了在光氧化还原条件下接触脂肪族醇的另一种方法。

  DOI：

  10.1021/acs.orglett.8b01885
• 作为试剂：
  描述：

  4-溴苯乙酮 、 3-吡啶硼酸 在 potassium phosphate 、 nickel(II) chloride hexahydrate 、 γ-diphenylphosphinopropyl alcohol 作用下， 以 异丙醇 为溶剂， 以99%的产率得到4-(3-吡啶)苯甲醛
  参考文献：
  名称：

  ProPhos：受转金属化机理启发的促进镍催化铃木-宫浦偶联的配体

  摘要：

  镍催化的铃木-宫浦偶联（Ni-SMC）具有降低制药工艺合成成本的潜力。然而，其应用受到反应速率慢、催化剂负载量高和杂环范围有限等挑战的限制。尽管最近进行了研究，但 Ni-SMC 中的金属转移机制（通常被视为限制营业额的步骤）仍然没有得到充分的了解。我们阐明了“Ni-oxo”金属转移途径，应用 PPh 2 Me 作为配体，并将镍-氧中间体的形成确定为周转限制步骤。基于这一见解，我们开发了一种支架配体 ProPhos，其特点是通过连接体与膦连接的羟基侧基。该设计预组织了亲核试剂和镍催化剂，从而促进金属转移。该催化剂在多种杂芳烃中表现出快速的动力学和强大的活性，催化剂负载量为 0.5–3 mol%。对于芳烃基材，催化剂负载量可以进一步降低至0.1 mol%。

  DOI：

  10.1021/jacs.4c00370

文献信息

• A Simple Synthesis and Some Synthetic Applications of Substituted Phosphide and Phosphinite Anions
  作者：E. N. Tsvetkov、N. A. Bondarenko、I. G. Malakhova、M. I. Kabachnik

  DOI：10.1055/s-1986-31510

  日期：——

  Based on data for the acidity relationship of phosphines and phosphinous acids and water in dimethyl sulfoxide and water, a simple method is reported for the generation of phosphide and phosphinite anions by the action of concentrated aqueous alkali on primary and secondary phosphines as well as phosphinous acids in dimethyl sulfoxide or other dipolar aprotic solvents. Alkylation of the anion yields secondary and tertiary phosphines, polyphosphines, functionally substituted phosphines as well as similarly substituted phosphine oxides. Phosphinous acids have been alkylated in various solvents in two-phase systems containing concentrated aqueous alkali and tetrabutylammonium iodide as phase transfer catalyst.

  基于二甲基亚砜和水中的膦和亚膦酸与水的酸度关系数据，报道了一种简单的方法，通过浓碱水溶液作用于二甲基亚砜或其他偶极非质子溶剂中的伯膦、仲膦及亚膦酸，生成膦化物和亚膦酸根阴离子。通过烷基化反应，这些阴离子可转化为仲膦、叔膦、多膦、功能化取代膦及其类似取代的膦氧化物。在含有浓碱和四丁基碘化铵作为相转移催化剂的两相体系中，亚膦酸已在多种溶剂中进行烷基化。
• Dendritic polymers containing a dimethylsilyl linked dihydroxybenzyl alcohol backbone: divergent synthesis, aggregation, functionalization, and an evaluation of their applications in catalysis
  作者：Olivier Bourrier、Ashok K. Kakkar

  DOI：10.1039/b301778h

  日期：——

  A divergent synthetic approach to the construction of dimethylsilyl linked dihydroxybenzyl alcohol based dendrimers via acid–base hydrolytic chemistry of bis(dimethylamino)dimethylsilane with 3,5-dihydroxybenzyl alcohol, is reported. The peripheral OH groups lead to significant aggregation that was studied using FT-IR and UV-Vis spectroscopies, light scattering and transmission electron microscopy. Different generations of dendrimers could be easily functionalized at the periphery with phosphorus donor groups that were subsequently bound to RhCl(1,5-C8H12). Such organometallic dendrimers were found to be active and recoverable catalysts for hydrogenation of decene. The catalytic efficiency was found to be dependent on the number of generations and reaction time. An uncontrolled reaction of Me2Si(NMe2)2 with 3,5-dihydroxybenzyl alcohol in a multi-step addition process or one-pot reaction, led to the formation of hyperbranched polymers in which the build-up of the polymeric backbone was found to be dependent on the preferential reactivity and sterics at the benzylic center, as observed during dendrimer construction.

  本文报道了一种通过酸碱水解法，利用双(二甲氨基)二甲基硅烷与3,5-二羟基苄醇反应，合成基于二甲基硅烷连接的二羟基苄醇基树枝状大分子的结果。通过FT-IR和UV-Vis光谱学、光散射和透射电子显微镜研究了外围羟基导致的重要聚集现象。不同代的树枝状大分子在外围可轻松引入磷供体基团，随后与RhCl(1,5-C8H12)结合。这些有机金属树枝状大分子被发现是用于癸烯加氢反应的活性可回收催化剂。催化效率取决于代数和反应时间。在多步加成过程或一步反应中，Me2Si(NMe2)2与3,5-二羟基苄醇的无控反应导致形成超支化聚合物，聚合物骨架的构建依赖于苄基中心的优先反应性和空间位阻，与树枝状大分子的构建过程观察到的情况一致。
• Electroluminescent iridium compounds with silylated, germanylated, and stannylated ligands, and devices made with such compounds
  申请人：Ionkin Alex Sergey

  公开号：US20080074033A1

  公开（公告）日：2008-03-27

  The present invention is directed to electroluminescent complexes of iridium(III) with silylated, germanylated and stannylated ligands. The invention is further directed to electronic devices in which the active layer includes an electroluminescent Ir(III) complex with silylated, germanylated and stannylated ligands.

  本发明涉及铱(III)与硅基、锗基和锡基配体形成的电致发光配合物。该发明还涉及电子器件，其中活性层包括具有硅基、锗基和锡基配体的电致发光铱(III)配合物。
• PROCESS FOR DIMERIZATION OF ETHYLENE TO BUT-1-ENE USING A COMPOSITION COMPRISING A TITANIUM-BASED COMPLEX AND AN ALKOXY LIGAND FUNCTIONALIZED BY A HETEROATOM
  申请人：GRASSET Fabian

  公开号：US20110288308A1

  公开（公告）日：2011-11-24

  The invention describes a process for the selective dimerization of ethylene to but-1-ene using a catalytic composition comprising at least one organometallic titanium complex, said organometallic complex containing at least one alkoxy type ligand functionalized by a heteroatom selected from nitrogen, oxygen, phosphorus, sulphur, arsenic and antimony or by an aromatic group.

  这项发明描述了一种利用含有至少一种有机金属钛配合物的催化组合物对乙烯进行选择性二聚化制备丁-1-烯的过程，所述有机金属配合物包含至少一种由氮、氧、磷、硫、砷和锑中选择的杂原子或芳香族基官能化的烷氧基配体。
• PROCESS FOR OLIGOMERIZATION OF OLEFINS THAT USES A CATALYTIC COMPOSITION THAT COMPRISES AN ORGANOMETALLIC COMPLEX THAT CONTAINS AN ALKOXY LIGAND THAT IS FUNCTIONALIZED BY A HETEROATOM
  申请人：IFP ENERGIES NOUVELLES

  公开号：US20130217941A1

  公开（公告）日：2013-08-22

  The invention describes a process for oligomerization of olefins into compounds or into a mixture of compounds of general formula CpH2p with 4≦p≦80 that employs a catalytic composition that comprises at least one organometallic complex of an element of group IV that is selected from among titanium, zirconium, or hafnium, whereby said organometallic complex contains at least one alkoxy-type ligand that is functionalized by a heteroatom that is selected from among nitrogen, oxygen, phosphorus or sulfur, or by an aromatic group.

  这项发明描述了一种将烯烃寡聚成一般化合物或化合物混合物的过程，其一般式为CpH2p，其中4≦p≦80，采用了包含至少一种来自IV族元素（钛、锆或铪）的有机金属配合物的催化组合物，该有机金属配合物至少包含一种被氮、氧、磷或硫选择的烷氧基配体，或者被芳香族基官能化。