毒理性
◉ 母乳喂养期间使用概述：美国不再销售用于人类的左旋咪唑，因为它可能引起粒细胞缺乏症，但在其他国家它被用作驱虫剂。关于其排入母乳的信息尚未有公开报道。一些信息表明，母亲在哺乳期间使用可能是可接受的。然而，由于在哺乳期间使用左旋咪唑的公开经验很少，因此可能会优先选择其他药物，特别是在哺乳新生儿或早产儿时。世界卫生组织建议在母亲接受左旋咪唑治疗期间不要进行母乳喂养。
◉ 对哺乳婴儿的影响：在刚果民主共和国，一个由33名母乳喂养的婴儿（喂养程度未说明）组成的队列被跟踪，他们的母亲在医院接受尼夫替莫克斯治疗。30位母亲接受了完整的30剂口服尼夫替莫克斯，剂量为每天15 mg/kg，并且所有人都接受了为期7天的静脉注射伊福林西，剂量为每天400 mg/kg，用于治疗非洲人类锥虫病（睡眠病）。其中6位哺乳母亲也服用了左旋咪唑。在所有哺乳婴儿中都没有报告严重的不良事件。
◉ 对泌乳和母乳的影响：截至修订日期，未找到相关的已发布信息。
◉ Summary of Use during Lactation:Levamisole is no longer marketed for human use in the United States because can cause agranulocytosis, but it is used as an anthelmintic in other countries. No published information is available about its excretion into breastmilk. Some information indicates that maternal use may be acceptable during breastfeeding. However, because there is little published experience with levamisole during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. The World Health Organization recommends against breastfeeding with maternal levamisole therapy.
◉ Effects in Breastfed Infants:A cohort of 33 infants who were breastfed (extent not stated) by hospitalized mothers taking nifurtimox was followed in the Democratic Republic of the Congo. Thirty mothers took a full course of 30 doses of oral nifurtimox 15 mg/kg daily and all received 14 doses of intravenous eflornithine 400 mg/kg daily for 7 days for human African trypanosomiasis. (sleeping sickness). Six nursing mothers also took levamisole. No serious adverse events were reported in any of the breastfed infants.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
