p-Hydroxybenzoylaceton | 51944-08-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-Hydroxybenzoylaceton
• 英文别名: 1-(4-Hydroxyphenyl)butane-1,3-dione
• CAS: 51944-08-2
• 化学式: C₁₀H₁₀O₃
• mdl: MFCD09996572
• 分子量: 178.188
• InChiKey: UWAUIJMZUFHKFS-UHFFFAOYSA-N

物化性质

• 熔点：
  112 °C
• 沸点：
  357.9±17.0 °C(Predicted)
• 密度：
  1.191±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-Hydroxybenzoylaceton 在 盐酸羟胺 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以61%的产率得到4-(3-methylisoxazol-5-yl)phenol
  参考文献：
  名称：

  Fitton, Alan O.; Patel, Rajeshkumar N.; Millar, Ross W., Journal of Chemical Research, Miniprint, 1986, # 4, p. 1101 - 1127

  摘要：

  DOI：

文献信息

• KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES
  申请人：BAILLY Frederic

  公开号：US20130012729A1

  公开（公告）日：2013-01-10

  The present disclosure relates to ketobenzofuran derivatives of the general formula (I): as well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

  本公开涉及一般式(I)的酮苯并呋喃衍生物，以及通过将醌亚胺和烯酰胺通过Nenitzescu反应偶联合成它们的方法，以及合成过程中的中间体。
• Inhibitors of Quorum Sensing Receptor LasR
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20190119201A1

  公开（公告）日：2019-04-25

  Modulation of quorum sensing in Gram-negative bacteria, particularly strains of Pseudomonas which form biofilms, by compounds including those of formula I and formula II: where: AR is optionally substituted phenyl, cycloalkyl or cycloalkenyl or heterocyclic, and R 1 is optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkylthioalkyl or alkyl substituted at the omega position with optionally substituted phenyl, cyclohexyl or cyclohexenyl. In particular compounds inhibit quorum sensing and biofilm formation. Pharmaceutical compositions for treatment of bacterial infections and methods of treatment of such infections are provided

  调节革兰氏阴性细菌中的群体感应，特别是形成生物膜的假单胞菌，通过包括公式I和公式II的化合物：其中：AR是可选取代的苯基，环烷基或环烯基或杂环基，而R1是可选取代的烷基，烯基，烷氧基烷基，或烷基硫代烷基或在ω位取代可选取代的苯基，环己基或环己烯基的烷基。特别的化合物抑制群体感应和生物膜形成。提供用于治疗细菌感染的制药组合物和治疗此类感染的方法。
• Verfahren zur Herstellung von p-Hydroxy-benzaldehyden
  申请人：BAYER AG

  公开号：EP0330036A1

  公开（公告）日：1989-08-30

  p-Hydroxy-benzaldehyde können durch Oxidation der zu­grundeliegenden p-Kresole mit Sauerstoff in Gegenwart basisch reagierender Stoffe in einem Lösungsmittel er­halten werden, wobei zusätzlich in Gegenwart eines Chelatkomplexes von Eisen und/oder Mangan gearbeitet wird. Gegebenenfalls kann in Gegenwart weiterer Metall­salze gearbeitet werden.

  对羟基苯甲醛可以通过在溶剂中存在碱性反应物质的情况下用氧气氧化底层的对甲酚来获得，也可以在存在铁和/或锰的螯合物的情况下进行。如有必要，还可以在有其他金属盐存在的情况下进行。
• Polydioxaborines
  申请人：——

  公开号：US20030220500A1

  公开（公告）日：2003-11-27

  Novel polydioxaborines are prepared by polymerizing novel monomers that contain a dioxaborine group. Polydioxaborines are readily soluble, excellent film formers, and have semiconducting properties useful in various applications.

  新型聚二氧硼烷是通过聚合含有二氧硼烷基团的新型单体而制备的。聚二噁硼烷易于溶解，成膜性极佳，并具有半导体特性，可用于各种用途。
• Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids
  作者：Antonio Caldarelli、Eleonora Penucchini、Diego Caprioglio、Armando A. Genazzani、Alberto Minassi

  DOI：10.1016/j.bmc.2013.05.053

  日期：2013.9

  A click-type entry into shortened curcuminoids of the diarylpentanoid type has been developed. The reaction is ideally suited to generate non-symmetrical analogues of curcumin, a class of natural products difficult to access but of growing biomedical relevance and special mechanistic interest to investigate the unique binding mode of curcumin to tubulin. Investigation of a series of click diarylpentane curcuminoids and their pyrazole adducts in various cellular tubulin functional assays validated this class of compounds as a novel type of anti-mitotic agents, evidencing structure-activity relationships, and identifying the pyrazole adduct 4k as a promising lead. (C) 2013 Elsevier Ltd. All rights reserved.