(E)-3-氯丙-2-烯腈 | 871-29-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: (E)-3-氯丙-2-烯腈
• 英文名称: 2-chloroacrylonitrile
• 英文别名: 2-Chloracrylnitril；beta-Chloroacrylonitrile；3-chloroprop-2-enenitrile
• CAS: 871-29-4
• 化学式: C₃H₂ClN
• 分子量: 87.5086
• InChiKey: DKFAYHWIVQDPCC-UHFFFAOYSA-N

物化性质

• 沸点：
  117-144 °C
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-3-氯丙-2-烯腈 在 氯 作用下， 生成 2,2,3,3-Tetrachlor-propionitril
  参考文献：
  名称：

  Determinants of mortality in patients with advanced cirrhosis after transjugular intrahepatic portosystemic shunting

  摘要：

  Background & Aims: Transjugular intrahepatic portosystemic shunt (TIPS) placement is effective in the treatment of complications of portal hypertension. This study evaluated the predictors of mortality in a group of cirrhotic patients with advanced liver disease after placement of TIPS. Methods: A retrospective analysis of all patients undergoing TIPS placement over a 2 1/2-year period was undertaken. Results: Fifty-six patients had TIPS placement for variceal hemorrhage, 49 for refractory ascites, and 24 for hepatic hydrothorax (total, 129). Of 21 variables available before TIPS placement, variceal hemorrhage requiring emergent TIPS placement (relative risk [RR], 37.5; 95% confidence interval [CI], 5.4-259) and bilirubin concentration >3.0 mg/dL (RR, 5.4; 95% CI, 1.4-10.2) were independent predictors of 30-day mortality. Variceal hemorrhage requiring emergent TIPS placement (hazard ratio [HR], 5.1, 95% CI, 2.2-9.1), alanine aminotransferase level >100 IU/L (HR, 2.5; 95% CI, 1.2-5.5), bilirubin level >3.0 mg/dL (HR, 2.6; 95% CI, 1.1-4.6), and pre-TIPS encephalopathy unrelated to bleeding (HR, 2.2; 95% CI, 1.2-4.8) independently predicted death during the follow-up period. A model was developed that separated the patients into 3 groups with significantly different survival rates. Conclusions: A clinical index consisting of 4 pre-TIPS variables can reliably predict outcome after TIPS.

  DOI：

  10.1016/s0016-5085(00)70422-7
• 作为产物：
  描述：

  乙炔 、 氯化氰 生成 (E)-3-氯丙-2-烯腈
  参考文献：
  名称：

  Bayer, Angewandte Chemie, 1949, vol. 61, p. 240

  摘要：

  DOI：

文献信息

• [EN] N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES<br/>[FR] SULFAMIDES N-(1-ARYLPYRAZOL-4L) ET LEUR UTILISATION EN TANT QU'ANTI-PARASITAIRES
  申请人：PFIZER LTD

  公开号：WO2005090313A1

  公开（公告）日：2005-09-29

  The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R1-R5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

  这项发明涉及一种化合物，其化学式为(I)的磺胺类化合物，或其在药学、兽医学或农业上可接受的盐或溶剂，其中R1-R5基团在描述中有所描述，以及包含这些化合物的组合物，其合成过程以及它们作为驱虫剂的用途。
• Synthesis of Optically Active <i>endo</i>,<i>endo</i> Bicyclo[2.2.2]octane-2,5-diol, Bicyclo[2.2.2]octane-2,5-dione, and Related Compounds
  作者：Fredrik Almqvist、Niklas Ekman、Torbjörn Frejd

  DOI：10.1021/jo9601167

  日期：1996.1.1

  5S)-bicyclo[2.2.2]octane-2,5-diol ((+)-12; 98% ee) and several selectively protected optically active intermediates useful for synthetic transformations were synthesized via a 1,2-carbonyl transposition route starting from the easily available optically active (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octan-2-one ((-)-2). The synthetic route also allowed the preparation of optically active (1S,4S)-bicyclo[2.2.2]octane-2

  旋光活性C（2）对称（1S，2S，4S，5S）-双环[2.2.2]辛烷-2,5-二醇（（+）-12; 98％ee）和几种选择性保护的旋光中间体有用通过容易获得的旋光性（1R，4S，6S）-6-羟基双环[2.2.2] octan-2-one（（-）-2）开始的1,2-羰基转座途径合成用于合成转化的化合物。合成路线还允许制备旋光的（1S，4S）-双环[2.2.2]辛烷-2，5-二酮（（+）-14； 98％ee）。
• Process for the preparation of insecticidal, nematicidal and acaricidal
  申请人：American Cyanamid Company

  公开号：US05106985A1

  公开（公告）日：1992-04-21

  There is provided a process for the preparation of 4-substituted-5-(trifluoromethyl)pyrrole-3-carbonitrile compounds which are useful as insecticidal, nematicidal and acaricidal agents.

  提供了一种制备4-取代-5-(三氟甲基)吡咯-3-腈类化合物的方法，该化合物可用作杀虫剂、杀线虫剂和杀螨剂。
• 1,2-Diarylimidazoles useful as inhibitors of cox
  申请人：Takahashi Fumie

  公开号：US20070043084A1

  公开（公告）日：2007-02-22

  A compound of the formula (1): wherein R 1 is cyano, and the like; R 2 is hydroxy, and the like; R 3 is (lower)alkoxy, and the like; X and Y are each CH or N; or pharmaceutically acceptable salts thereof, which are useful as a medicament.

  公式（1）的化合物：其中R1为氰基等；R2为羟基等；R3为（低）烷氧基等；X和Y分别为CH或N；或其药学上可接受的盐，其可用作药物。
• US2419488
  申请人：——

  公开号：——

  公开（公告）日：——