Methyl <2-(tetrahydropyranyloxy)phenyl>acetate | 153623-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Methyl <2-(tetrahydropyranyloxy)phenyl>acetate
• 英文别名: methyl 2-tetrahydropyranyloxyphenyl-acetate；Methyl 2-[2-(oxan-2-yloxy)phenyl]acetate
• CAS: 153623-45-1
• 化学式: C₁₄H₁₈O₄
• 分子量: 250.295
• InChiKey: DEVCTGUHMGGEFO-UHFFFAOYSA-N

物化性质

• 沸点：
  354.0±37.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)
• 溶解度：
  二氯甲烷；

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl <2-(tetrahydropyranyloxy)phenyl>acetate 在 lithium aluminium tetrahydride 、 对甲苯磺酸 、 pyridinium chlorochromate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 42.5h， 生成 2-(2-hydroxyphenyl)propionaldehyde
  参考文献：
  名称：

  Asymmetric induction reactions. V. The palladium-catalyzed asymmetric .alpha.-allylation of carbonyl compounds with chiral allyl esters via enamines and imines

  摘要：

  A novel and excellent method for asymmetric alpha-allylation of carbonyl compounds via their chiral enamines or imines bearing allyl eaters has been developed. Readily available chiral allyl eaters having chirality at the alpha-position of the eater carbonyl group, such as (S)-proline and other (S)-alpha-amino acid allyl esters, have been found to serve as good asymmetric allylating reagents in palladium-catalyzed reactions of the chiral enamines and imines derived from them. The use of (S)-proline or (S)-valine allyl esters as the amino parts in the enamines or imines provided the highest optical yields of the corresponding alpha-allyl carbonyl compounds. A mechanism for asymmetric induction is proposed based on the stereochemical results obtained.

  DOI：

  10.1021/jo00080a033
• 作为产物：
  描述：

  邻羟基苯乙酸 在 硫酸 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 22.0h， 生成 Methyl <2-(tetrahydropyranyloxy)phenyl>acetate
  参考文献：
  名称：

  Asymmetric induction reactions. V. The palladium-catalyzed asymmetric .alpha.-allylation of carbonyl compounds with chiral allyl esters via enamines and imines

  摘要：

  A novel and excellent method for asymmetric alpha-allylation of carbonyl compounds via their chiral enamines or imines bearing allyl eaters has been developed. Readily available chiral allyl eaters having chirality at the alpha-position of the eater carbonyl group, such as (S)-proline and other (S)-alpha-amino acid allyl esters, have been found to serve as good asymmetric allylating reagents in palladium-catalyzed reactions of the chiral enamines and imines derived from them. The use of (S)-proline or (S)-valine allyl esters as the amino parts in the enamines or imines provided the highest optical yields of the corresponding alpha-allyl carbonyl compounds. A mechanism for asymmetric induction is proposed based on the stereochemical results obtained.

  DOI：

  10.1021/jo00080a033

文献信息

• Fluoromethoxyacrylic acid derivatives and their use as pest control agents
  申请人：Bayer Aktiengesellschaft

  公开号：US06337401B1

  公开（公告）日：2002-01-08

  The invention relates to new fluoromethoxyacrylic acid derivatives, a process for their preparation and their use as pesticides, as well as to new intermediates and a plurality of processes for their preparation. It has already been disclosed that certain fluoromethoxyacrylic acid derivatives which are similar in constitution to the compounds described below have fungicidal properties (compare, for example, WO 9517376). The fungicidal action of these compounds, however, is unsatisfactory in many cases.

  本发明涉及新的氟甲氧基丙烯酸衍生物，其制备方法以及它们作为杀虫剂的用途，以及新的中间体和多种制备它们的方法。已经披露了某些与下述化合物相似的氟甲氧基丙烯酸衍生物具有杀真菌作用（例如参见WO 9517376）。然而，这些化合物的杀真菌作用在许多情况下是不令人满意的。
• The synthesis of quinone methides from p-quinol benzoates
  作者：Allen J Guildford、Ralph W Turner

  DOI：10.1016/s0040-4039(01)92357-3

  日期：1981.1
• US5679676A
  申请人：——

  公开号：US5679676A

  公开（公告）日：1997-10-21
• US5883250A
  申请人：——

  公开号：US5883250A

  公开（公告）日：1999-03-16