3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole | 452098-14-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole
• 英文别名: 3-[2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy]-5-methyl-1H-pyrazole
• CAS: 452098-14-5
• 化学式: C₁₁H₇ClF₄N₂O
• 分子量: 294.636
• InChiKey: CLQCZRRHBJBNKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole 、 异氰酸甲酯 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 4.0h， 以55.9%的产率得到N-methyl-3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole-1-carboxamide
  参考文献：
  名称：

  PYRAZOLE DERIVATIVE, INTERMEDIATE THEREFOR, PROCESSES FOR PRODUCING THESE, AND HERBICIDE CONTAINING THESE AS ACTIVE INGREDIENT

  摘要：

  公开号：

  EP1362852B1
• 作为产物：
  描述：

  3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole-1-carboxylic acid methyl ester 在 sodium hydroxide 水 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以88.2%的产率得到3-(2-chloro-6-fluoro-4-trifluoromethylphenyloxy)-5-methylpyrazole
  参考文献：
  名称：

  WO2006/126692

  摘要：

  公开号：

文献信息

• Pyrazole derivative, intermediate therefor, processes for producing these, and herbicide containing these as active ingredient
  申请人：Hirai Kenji

  公开号：US20050070441A1

  公开（公告）日：2005-03-31

  The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the production thereof, and a herbicide containing the derivative as an active ingredient.

  本发明提供了一种通式（1）的吡唑衍生物，该衍生物作为除草剂的活性成分具有优异的功效，还提供了其生产的中间体、生产过程以及以该衍生物作为活性成分的除草剂。
• PYRAZOLE-1-CARBOXYLATE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND PROCESS FOR THE PRODUCTION OF PYRAZOLE DERIVATIVES
  申请人：Uchida Atsushi

  公开号：US20090018345A1

  公开（公告）日：2009-01-15

  Disclosed are pyrazole-1-carboxylate derivatives of the general formula (1), (wherein symbols are as defined in the specification), a process for the production thereof and processes for producing herbicidally active 3-aryloxypyrazole-1-carboxamide derivatives from the above compound and an intermediate therefor. According to this invention, there can be industrially advantageously produced 3-aryloxypyrazole-1-carboxamide derivatives that does not cause chemical damage on crops but exhibits excellent herbicidal activity against weeds that impair the growth of such crops.

  本发明涉及一般式（1）的吡唑-1-羧酸酯衍生物（其中符号如规范中所定义），其生产过程以及从上述化合物和中间体生产除草活性3-芳基氧基吡唑-1-羧酰胺衍生物的过程。根据本发明，可以工业上优势地生产不会对作物造成化学损害但对妨碍作物生长的杂草表现出优异的除草活性的3-芳基氧基吡唑-1-羧酰胺衍生物。
• Pyrazole-1-carboxylate derivatives, process for the production thereof and process for the production of pyrazole derivatives
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：US07767827B2

  公开（公告）日：2010-08-03

  Disclosed are pyrazole-1-carboxylate derivatives of the general formula (1), (wherein symbols are as defined in the specification), a process for the production thereof and processes for producing herbicidally active 3-aryloxypyrazole-1-carboxamide derivatives from the above compound and an intermediate therefor. According to this invention, there can be industrially advantageously produced 3-aryloxypyrazole-1-carboxamide derivatives that does not cause chemical damage on crops but exhibits excellent herbicidal activity against weeds that impair the growth of such crops.

  本发明公开了一般式（1）的吡唑-1-羧酸酯衍生物（其中符号如规范中定义），其制备方法以及从上述化合物和其中间体制备除草活性3-芳基氧基吡唑-1-羧酰胺衍生物的方法。根据本发明，可以工业上优势地生产不会对作物造成化学损害但对损害这些作物生长的杂草具有优异除草活性的3-芳基氧基吡唑-1-羧酰胺衍生物。
• PYRAZOLE-1-CARBOXYLIC ESTER DERIVATIVE, METHOD FOR PRODUCING THE SAME AND METHOD FOR PRODUCING PYRAZOLE DERIVATIVE
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1884512A1

  公开（公告）日：2008-02-06

  Disclosed are pyrazole-1-carboxylate derivatives of the general formula (1), (wherein symbols are as defined in the specification), a process for the production thereof and processes for producing herbicidally active 3-aryloxypyrazole-1-carboxamide derivatives from the above compound and an intermediate therefor. According to this invention, there can be industrially advantageously produced 3-aryloxypyrazole-1-carboxamide derivatives that does not cause chemical damage on crops but exhibits excellent herbicidal activity against weeds that impair the growth of such crops.

  所公开的是通式（1）的吡唑-1-羧酸盐衍生物、 (其中符号如说明书中所定义）的吡唑-1-甲酸酯衍生物、其生产工艺以及由上述化合物及其中间体生产具有除草活性的 3-芳氧基吡唑-1-甲酰胺衍生物的工艺。 根据本发明，可以在工业上生产出不会对农作物造成化学损害，但对妨碍农作物生长的杂草具有优异除草活性的 3-芳氧基吡唑-1-甲酰胺衍生物。
• Pyrazole derivative, its intermediate, and herbicide containing the same as active ingredient
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP2292606A1

  公开（公告）日：2011-03-09

  The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the production of the intermediate, and a herbicide containing the derivative as an active ingredient.

  本发明提供了通式（1）的吡唑衍生物、 本发明提供了一种作为除草剂活性成分具有优异功效的吡唑衍生物、一种用于生产该衍生物的中间体、生产该中间体的工艺以及一种含有该衍生物作为活性成分的除草剂。