(1S,2R)-2-(2-(diphenylphosphino)benzamido)-1-phenylpropyl 2-(diphenylphosphino)benzoate | 1262962-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2R)-2-(2-(diphenylphosphino)benzamido)-1-phenylpropyl 2-(diphenylphosphino)benzoate
• 英文别名: [(1S,2R)-2-[(2-diphenylphosphanylbenzoyl)amino]-1-phenylpropyl] 2-diphenylphosphanylbenzoate
• CAS: 1262962-01-5
• 化学式: C₄₇H₃₉NO₃P₂
• 分子量: 727.779
• InChiKey: MAZMSMPPKYXBPZ-OEMUZABFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  53
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-二苯基膦苯甲酸 、 左旋去甲麻黄碱 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以50%的产率得到(1S,2R)-2-(2-(diphenylphosphino)benzamido)-1-phenylpropyl 2-(diphenylphosphino)benzoate
  参考文献：
  名称：

  Palladium catalyzed asymmetric sulfonylation mediated chiral β-hydroxy- and β-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides

  摘要：

  The palladium catalyzed asymmetric allylic sulfonylation reaction has been investigated employing beta-hydroxy- and beta-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides as chiral non-racemic ligands The bisphosphine beta-benzoyloxybenzamide ligands proved to be the best ligands for this process Competitive transition states for the (1S 2R)-norephedrine derived ligand 14 are compared and a rationale is provided for the observed enantioselectivities (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.10.022
• 作为试剂：
  描述：

  1,3-二苯基-2-丙烯基乙酸酯 、 丙二酸二甲酯 在 N,O-双三甲硅基乙酰胺 、 bis(η3-allyl-μ-chloropalladium(II)) 、 (1S,2R)-2-(2-(diphenylphosphino)benzamido)-1-phenylpropyl 2-(diphenylphosphino)benzoate 、 potassium acetate 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-dimethyl 2-(1,3-diphenylallyl)malonate 、 (S)-dimethyl 2-(1,3-diphenylallyl)malonate
  参考文献：
  名称：

  Palladium catalyzed asymmetric sulfonylation mediated chiral β-hydroxy- and β-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides

  摘要：

  The palladium catalyzed asymmetric allylic sulfonylation reaction has been investigated employing beta-hydroxy- and beta-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides as chiral non-racemic ligands The bisphosphine beta-benzoyloxybenzamide ligands proved to be the best ligands for this process Competitive transition states for the (1S 2R)-norephedrine derived ligand 14 are compared and a rationale is provided for the observed enantioselectivities (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.10.022

文献信息

• Palladium catalyzed asymmetric sulfonylation mediated chiral β-hydroxy- and β-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides
  作者：Jesse A. Wolfe、Shawn R. Hitchcock

  DOI：10.1016/j.tetasy.2010.10.022

  日期：2010.11

  The palladium catalyzed asymmetric allylic sulfonylation reaction has been investigated employing beta-hydroxy- and beta-(o-diphenylphosphino)benzoyloxy (o-diphenyl phosphino)benzamides as chiral non-racemic ligands The bisphosphine beta-benzoyloxybenzamide ligands proved to be the best ligands for this process Competitive transition states for the (1S 2R)-norephedrine derived ligand 14 are compared and a rationale is provided for the observed enantioselectivities (C) 2010 Elsevier Ltd All rights reserved