四苯基硅烷 | 1048-08-4

• 物质功能分类: 化学试剂 - 硅烷试剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 四苯基硅烷
• 中文别名: 四苯矽[烷]
• 英文名称: tetraphenylsilane
• 英文别名: TPS
• CAS: 1048-08-4
• 化学式: C₂₄H₂₀Si
• mdl: MFCD00014069
• 分子量: 336.508
• InChiKey: JLAVCPKULITDHO-UHFFFAOYSA-N

物化性质

• 熔点：
  236 °C
• 沸点：
  228 °C
• 密度：
  1.078
• 闪点：
  193°C
• 稳定性/保质期：
  在常温常压下保持稳定，应避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  6.45
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  Yes
• 安全说明：
  S22,S24/25
• 海关编码：
  29319090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  请将容器密封保存，并存放在阴凉、干燥处。

SDS

Tetraphenylsilane Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Tetraphenylsilane

Revision number: 5

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols None
No signal word
Signal word
Hazard statements None
None
Precautionary statements:

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Tetraphenylsilane
Percent: >97.0%(GC)
CAS Number: 1048-08-4
Chemical Formula: C24H20Si

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Tetraphenylsilane

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Section 5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store under inert gas.
Protect from moisture.
Store away from incompatible materials such as oxidizing agents.
Moisture-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Crystal- Powder
Form:
Colour: White - Almost white
No data available
Odour:
pH: No data available
Melting point/freezing point:238°C
Boiling point/range: 166°C/0.01kPa
No data available
Flash point:
Flammability or explosive
limits:
Lower: No data available
No data available
Upper:
Relative density: No data available
Solubility(ies):
[Water] No data available
Tetraphenylsilane

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Silicon oxides
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
No data available
NTP =
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
Tetraphenylsilane

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生产方法可以通过两种方式来实现：

1. 可由八氯三硅烷与苯基溴化镁反应来制取。
2. 也可以通过正硅酸乙酯与苯基溴化镁的反应得到，之后蒸除剩余的正硅酸乙酯，并在甲苯溶液中回流以完成反应。

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  三苯基硅烷	HSiPh3	789-25-3	C18H16Si	260.411
  二苯基硅烷	diphenylsilane	775-12-2	C12H12Si	184.313
  甲基三苯基硅烷	methyltriphenylsilane	791-29-7	C19H18Si	274.437
  三苯基硅醇	triphenylhydroxysilane	791-31-1	C18H16OSi	276.41
  ——	triphenylsilyl bromide	6990-64-3	C18H15BrSi	339.307
  三苯基氯硅烷	Triphenylchlorosilane	76-86-8	C18H15ClSi	294.856
  三苯甲基氟硅烷	triphenylsilyl fluoride	379-50-0	C18H15FSi	278.401

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	Si(ph-3-NH2)4	18751-12-7	C24H24N4Si	396.567
  4,4’-双(三苯基硅基)-1,1’-联苯	4,4'-bis(triphenylsilyl)biphenyl	18826-13-6	C48H38Si2	671.001
  甲基三苯基硅烷	methyltriphenylsilane	791-29-7	C19H18Si	274.437
  三苯基硅醇	triphenylhydroxysilane	791-31-1	C18H16OSi	276.41
  ——	triphenylsilyl bromide	6990-64-3	C18H15BrSi	339.307
  三苯基氯硅烷	Triphenylchlorosilane	76-86-8	C18H15ClSi	294.856

反应信息

• 作为反应物：
  描述：

  四苯基硅烷 在 四氯化硅 、 copper(l) chloride 作用下， 生成 三苯基氯硅烷
  参考文献：
  名称：

  Soschestwenskaja, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 231; engl.Augs.S.247

  摘要：

  DOI：
• 作为产物：
  描述：

  三苯基氯硅烷 在 CH₃MgI 、 Cl₂ 作用下， 以 乙醚 为溶剂， 生成 四苯基硅烷
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 23, page 72 - 75

  摘要：

  DOI：
• 作为试剂：
  描述：

  肉桂基氯 在 iron(III) chloride 、 四苯基硅烷 作用下， 以 叔丁醇 为溶剂， 反应 24.0h， 以90%的产率得到3-氯代苯丙酮
  参考文献：
  名称：

  一种铁催化氧化烯合成酮的方法

  摘要：

  本发明公开了一种铁催化氧化烯合成酮的方法，属于催化合成技术和精细化学品合成领域。本发明的具体方法是在氢硅烷的促进作用下，以空气或氧气为氧化剂，铁催化氧化烯合成酮类化合物。本发明方法具有催化剂来源广泛、廉价和环保的优势；氧化剂来源广泛、廉价和不产生废物；反应条件温和、选择性高和产率高；底物来源广泛且稳定；底物官能团相容性好且底物的适用范围广；复杂烯分子能很好的转化成酮。在优化的反应条件之下，目标产品分离收率高达98%。

  公开号：

  CN106748690B

文献信息

• Fluoride-Promoted Cross-Coupling of Chloro(mono-, di-, or triphenyl)germanes with Aryl Halides in “Moist” Toluene. Multiple Transfer of the Phenyl Group from Organogermane Substrates and Comparison of the Coupling Efficiencies of Chloro(phenyl)germanes with their Corresponding Stannane and Silane Counterparts
  作者：Jean-Philippe Pitteloud、Zun-Ting Zhang、Yong Liang、Laura Cabrera、Stanislaw F. Wnuk

  DOI：10.1021/jo101848f

  日期：2010.12.3

  efficient activation by fluoride to promote transfer of one, two, or three phenyl groups from the organogermanes. The corresponding chlorophenylstannanes were found to be more reactive than chlorophenylsilanes, which in turn were more effective than chlorophenylgermanes. One chloride ligand on the Ge or Si center allows efficient activation by fluoride to promote transfer of up to three aryl groups

  三氯苯基-、二氯二苯基-和氯三苯基锗烷在四丁基氟化铵的甲苯中加入测量的水量。Ge 中心的一个氯化物配体允许氟化物有效活化，以促进一个、两个或三个苯基基团从有机锗烷转移。发现相应的氯苯基锡烷比氯苯基硅烷更具反应性，而氯苯基硅烷又比氯苯基锗烷更有效。Ge 或 Si 中心的一个氯化物配体允许氟化物有效活化，以促进多达三个芳基从锗烷或硅的转移。然而，Sn 中心不需要卤配体，因为在氟化物促进的与芳基卤化物的偶联过程中，四苯基锡有效地转移了多达四个苯基。19 F NMR 研究表明，氟苯基锗烷和高价锗酸盐物质的形成可能是中间体。
• Carbonylative coupling reaction of organofluorosilanes with organic halides promoted by fluoride ion and palldium catalyst
  作者：Yasuo Hatanaka、Satoshi Fukushima、Tamejiro Hiyama

  DOI：10.1016/s0040-4020(01)88878-5

  日期：1992.1

  Palladium-catalyzed carbonylative cross coupling reaction of organofluorosilanes with organic halides was achieved in the presence of fluoride ion and an atmospheric pressure of carbon monoxide. Alkenyl- or arylfluorosilanes effectively underwent this reaction with alkenyl or aryl iodides in moderate to good yields. Thus, highly functionalized ketones are readily available without protection of reactive

  在氟离子和一氧化碳的大气压下，实现了有机氟硅烷与有机卤化物的钯催化羰基交叉偶联反应。烯基-或芳基氟硅烷与烯基或芳基碘化物有效地进行该反应，产率中等至良好。因此，在不保护反应性官能团例如醛，酮，酯，腈和醇的情况下，容易获得高度官能化的酮。为了顺利生成酮，必须使用有机氟硅烷。与芳基碘化物反应后，四芳基硅烷（如芳基（三甲基）硅烷）代替芳酰氟。
• Reactivity of Hypervalent Species: Reactions of Anionic Penta-Coordinated Silicon Complexes towards Nucleophiles
  作者：Alain Boudin、Geneviève Cerveau、Claude Chuit、Robert J. P. Corriu、Catherine Reye

  DOI：10.1246/bcsj.61.101

  日期：1988.1

  The reactivity of anionic penta-coordinated silicon complexes [RSi(O2C6H4-o)2]−Na+ 1 with nucleophilic reagents has been studied. 1 can be reduced to organosilanes RSiH3 by metallic hydrides. Reactions with an excess of Grignard or organolithium reagents (R′MgX or R′Li) gave tetraorganosilanes RSiR′3. When only two molar equivalents of Grignard reagents (R′MgX) or lithium reagents (R′Li) are added

  已经研究了阴离子五配位硅配合物 [RSi(O2C6H4-o)2]-Na+1 与亲核试剂的反应性。1 可以被金属氢化物还原为有机硅烷 RSiH3。与过量的格氏试剂或有机锂试剂（R'MgX 或 R'Li）反应得到四有机硅烷 RSiR'3。当仅将两摩尔当量的格氏试剂 (R'MgX) 或锂试剂 (R'Li) 添加到配合物 1 时，可以制备功能性硅烷 RR'2SiX。
• Disproportionation reactions of organohydrosilanes in the presence of base catalysts
  作者：Masayoshi Itoh、Koji Inoue、Jun-ichi Ishikawa、Kenji Iwata

  DOI：10.1016/s0022-328x(01)00755-0

  日期：2001.6

  Alkoxides, alkyl compounds, amides and hydrides of alkali metals (M) and barium, such as MOR, Ba(OR)2, n-BuM, PhM, MN(SiMe3)2 and MAlH4 showed high catalytic activities versus the disproportionation reactions of PhSiH3 to produce SiH4, Ph2SiH2 and Ph3SiH. A good correlation between the catalyst basicities and the catalytic activities was observed, and a reaction mechanism involving the metal hydride

  碱金属（M）和钡的醇盐，烷基化合物，酰胺和氢化物，例如MOR，Ba（OR）2，n- BuM，PhM，MN（SiMe 3）2和MAlH 4与歧化反应相比具有较高的催化活性用PhSiH 3制备SiH 4，Ph 2 SiH 2和Ph 3 SiH。观察到催化剂碱性和催化活性之间的良好相关性，并提出了涉及金属氢化物和烷基金属的反应机理。的SiH的相当数量4在PhSiCl的还原产生的3用的LiAlH 4当使用超过三摩尔的LiAlH 4时。
• Pentacoordinate silicon compounds. Reactions of silatranes with nucleophiles
  作者：G. Cerveau、C. Chuit、R.J.P. Corriu、N.K. Nayyar、C. Reye

  DOI：10.1016/0022-328x(90)85408-q

  日期：1990.6

  studied. Substitution involving cleavage of equatorial SiO bonds is always observed. Silatranes exhibit reactivity quite different from that of analogous trialkoxysilanes or anionic pentacoordinate silicon compounds.

  已经研究了氢，有机基和卤代硅烷基团与亲核试剂的反应。总是观察到涉及赤道SiO键断裂的取代。Silatranes的反应性与类似的三烷氧基硅烷或阴离子五配位硅化合物完全不同。

表征谱图