N.N'-Ethylenbis-butyramid | 925-49-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N.N'-Ethylenbis-butyramid
• 英文别名: N,N'-ethanediyl-bis-butyramide；N,N'-Aethandiyl-bis-butyramid；N-[2-(butanoylamino)ethyl]butanamide
• CAS: 925-49-5
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.281
• InChiKey: AIWAFUBJIYAIGI-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.24 M

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N.N'-Ethylenbis-butyramid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 N1,n2-二丁基乙烷-1,2-二胺
  参考文献：
  名称：

  N,N'-Dialkyloxamides¹

  摘要：

  DOI：

  10.1021/ja01097a516
• 作为产物：
  描述：

  丁酸丁酯 、 乙二胺 在 carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II) 、 potassium tert-butylate 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以78%的产率得到N.N'-Ethylenbis-butyramid
  参考文献：
  名称：

  An efficient, green and scale-up synthesis of amides from esters and amines catalyzed by Ru-MACHO catalyst under mild conditions

  摘要：

  An efficient, green and scale-up synthesis of amides from esters and amines has been developed using Ru-MACHO as a readily available catalyst. A diverse range of amides were obtained in moderate to excellent yields (55-98%). Furthermore, when the scale of the amidation reaction was increased to 240.0 mmol, the desired amide still could be obtained in high yield (48.2 g of N-benzylbenzamide, 95%). (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2014.08.036

文献信息

• TEMPERATURE MANAGEMENT INDICATOR AND STRUCTURE HAVING THE SAME ATTACHED
  申请人：Nichiyu Giken Kogyo Co. Ltd.

  公开号：EP2554961A1

  公开（公告）日：2013-02-06

  A temperature management indictor having simple structure is provided, which, not containing a hazardous metal, especially mercury among others, is safe and excellently durable, especially durable against light and repetition of heating and cooling cycle, is capable of indicating specific temperature ranges by means of reversible color changes, and also is able, as need be, to indicate an arrival at a specific temperature by means of an irreversible color change. A temperature management indicator 10 comprises; a reversible temperature indicating member 14 including reversible temperature indicating pigment particles devoid of mercury, which reversibly undergoes color changes at a predetermined temperature, wherein in the reversible temperature indicating member 14, the reversible temperature indicating pigment particles contain an iron-containing complex compound and are dispensed to be dispersed in a resin thereof.

  本发明提供了一种结构简单的温度管理指示器，该指示器不含有害金属，特别是汞，安全耐用，特别是耐光和耐重复加热和冷却循环，能够通过可逆的颜色变化指示特定的温度范围，也能够根据需要通过不可逆的颜色变化指示到达特定温度。温度管理指示器 10 包括：可逆温度指示部件 14，其中包括不含汞的可逆温度指示颜料颗粒，该颜料颗粒在预定温度下可逆地发生颜色变化，其中在可逆温度指示部件 14 中，可逆温度指示颜料颗粒包含含铁的复合化合物，并被分配分散在其树脂中。
• Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
  申请人：THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH

  公开号：US10039809B2

  公开（公告）日：2018-08-07

  Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

  提供了延长治疗剂半衰期的方法和组合物。改性治疗剂（mTA）由治疗剂、主食和延长半衰期分子组成。本文公开的 mTA 可用于治疗有需要的受试者的疾病或病症。
• Normal Fatty Acid Amides of Ethylenediamine
  作者：N. Beverley Tucker

  DOI：10.1021/ja01313a069

  日期：1935.10
• Synthesis of acylated (2?-hydroxyethyl)amino- and (2?-aminoethyl)amino-1,3,5-triazines
  作者：Zh. Z. Sapozhnikova、A. F. Prokof 'eva、T. I. Koroleva、N. N. Mel'nikov

  DOI：10.1007/bf00512971

  日期：1982.2
• Some Alkyl-glyoxalidines¹
  作者：Henry C. Chitwood、E. Emmet Reid

  DOI：10.1021/ja01315a030

  日期：1935.12