[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-2-(4-hydroxy-1H-indol-3-yl)-N-sulfooxyethanimidothioate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-2-(4-hydroxy-1H-indol-3-yl)-N-sulfooxyethanimidothioate
• 化学式: C₁₆H₂₀N₂O₁₀S₂
• 分子量: 464.5
• InChiKey: CSMYCLLHRFFFLG-ABVFHMHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  236
• 氢给体数：
  7
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-2-(4-hydroxy-1H-indol-3-yl)-N-sulfooxyethanimidothioate 、 三甲基氯硅烷 生成 [(2S,3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-yl] (1E)-2-(4-hydroxy-1H-indol-3-yl)-N-trimethylsilyloxyethanimidothioate
  参考文献：
  名称：

  SHAW, G. JOHN;ANDRZEJEWSKI, DENIS;ROACH, JOHN A. G.;SPHON, JAMES A., J. AGR. AND FOOD CHEM., 38,(1990) N, C. 616-619

  摘要：

  DOI：

文献信息

• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

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• OILSEED PROTEIN CONCENTRATE AND PROCESS FOR THE PRODUCTION THEREOF
  申请人：Avril

  公开号：EP3935951A1

  公开（公告）日：2022-01-12

  A process for producing a protein concentrate from oilseed from a plant of a family selected from the group consisting of Brassicaceae, Cannabaceae, Pedaliaceae, Rosaceae, and Fabaceae, preferably Brassicaceae. The method comprises the successive steps of: a) providing a presscake from at least partially dehulled oilseed; b) washing said presscake by mixing it with a first hydrous-alcohol solvent to obtain a washed presscake, and eventually separating said washed presscake from said first hydrous-alcohol solvent, to obtain a washed, an eventually separated, presscake, wherein said first hydrous-alcohol solvent has an alcohol concentration ranging from 60 % to 75% w/w; and c) washing said washed, and eventually separated presscake by mixing it with a last hydrous-alcohol solvent to obtain a protein-containing solid and separating said protein-containing solid from said last hydrous-alcohol solvent to obtain a protein concentrate, wherein the alcohol concentration of the final hydrous-alcohol solvent is about the concentration of the azeotrope.

  一种利用选自十字花科、大麻科、佩德利亚科、蔷薇科和豆科植物（最好是十字花科）的油籽生产浓缩蛋白的方法。该方法包括以下连续步骤 a) 从至少部分脱壳的油籽中提供榨饼； b) 将所述压榨饼与第一水合醇溶剂混合进行洗涤，以获得洗涤后的压榨饼，并最终将所述洗涤后的压榨饼与所述第一水合醇溶剂分离，以获得洗涤后并最终分离的压榨饼，其中所述第一水合醇溶剂的醇浓度为 60% 至 75% w/w；以及 c) 通过与最后一种含水酒精溶剂混合来洗涤所述经洗涤并最终分离的压饼，以获得含蛋白质的固体，并从所述最后一种含水酒精溶剂中分离所述含蛋白质的固体，以获得蛋白质浓缩物，其中最后一种含水酒精溶剂的酒精浓度约为共沸物的浓度。
• Maca compositions and methods of use
  申请人：JDS Therapeutics, LLC

  公开号：US10265364B2

  公开（公告）日：2019-04-23

  The present application is directed to composition comprising various maca extracts and the use of such compositions for treating certain diseases, disorders, and conditions.

  本申请涉及由各种玛卡提取物组成的组合物，以及使用此类组合物治疗某些疾病、失调和病症。
• Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals
  申请人：VEIJLEN N.V.

  公开号：US10716778B2

  公开（公告）日：2020-07-21

  The present disclosure relates to the use of one or more compounds that are capable of increasing the serum level of insulin-like growth factor 1 (IGF-1) for the preparation of a therapeutical composition, in particular, in the form of a food supplement, for the treatment of subjects suffering from serious fatigue and exhausting symptoms, burn-out and chronic fatigue syndrome. The same composition can also be used by patients suffering from depression, Alzheimer disease, irritated bowel syndrome, osteoporosis, type 2 diabetes, or for anti-aging, immune therapy and recovery after exercise. The composition also has a use in veterinary applications for increasing the growth and immunity in animals.

  本公开涉及一种或多种能够提高血清中胰岛素样生长因子1（IGF-1）水平的化合物用于制备治疗组合物，特别是以食品补充剂的形式，用于治疗患有严重疲劳和疲惫症状、倦怠和慢性疲劳综合征的患者。同样的组合物还可用于抑郁症、老年痴呆症、肠易激综合征、骨质疏松症、2 型糖尿病患者，或用于抗衰老、免疫疗法和运动后恢复。该成分还可用于兽医领域，提高动物的生长速度和免疫力。
• Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands
  申请人：——

  公开号：US20020147155A1

  公开（公告）日：2002-10-10

  Disclosed are methods of treating endometriosis in a woman or of preventing endometriosis in a woman at higher than normal risk of developing or suffering recurrence of endometriosis. The inventive methods involve administering to the woman a pharmaceutically acceptable composition containing an aryl hydrocarbon receptor binding ligand, such as indole-3-carbinol, indole-4-carbinol, indole-5-carbinol, diindolylmethane, tryptophan, tryptamine, indole acetic acid, or glucosinolate compounds.

  本发明公开了治疗妇女子宫内膜异位症或预防子宫内膜异位症的方法。 本发明的方法是给妇女服用一种药学上可接受的组合物，该组合物含有芳基烃受体结合配体，如吲哚-3-甲醇、吲哚-4-甲醇、吲哚-5-甲醇、二吲哚甲烷、色氨酸、色胺、吲哚乙酸或葡糖苷酸化合物。