(1S,2R)-2-Methyl-4-oxocyclopentanecarboxylic acid | 141978-98-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,2R)-2-Methyl-4-oxocyclopentanecarboxylic acid
• 英文别名: (3S,4R)-3-carboxy-4-methylcyclopentanone；cis-2-methyl-4-oxocyclopentanecarboxylic acid；(3S, 4R)-3-carboxy-4-methylcyclopentanone；(1S,2R)-2-methyl-4-oxocyclopentane-1-carboxylic acid
• CAS: 141978-98-5
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: IKCRKYGDJYISMR-XINAWCOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,2R)-2-Methyl-4-oxocyclopentanecarboxylic acid 生成 Nα-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prolinamide monohydrate
  参考文献：
  名称：

  Novel peptide derivatives and their pharmaceutical use

  摘要：

  公开号：

  EP0384380B1
• 作为产物：
  描述：

  (3S,4R)-3-methoxycarbonyl-4-methylcyclopentanone 在 三甲基氯硅烷 、 sodium iodide 、 sodium thiosulfate 作用下， 以 氯仿 、 水 、 乙腈 为溶剂， 生成 (1S,2R)-2-Methyl-4-oxocyclopentanecarboxylic acid
  参考文献：
  名称：

  Novel peptide derivatives and their pharmaceutical use

  摘要：

  公开号：

  EP0384380B1

文献信息

• Cyclohexene derivative and method of producing the same
  申请人：Japan Tobacco Inc.

  公开号：US05329042A1

  公开（公告）日：1994-07-12

  Provided is a novel (1R, 2S)-1-acyl-2-carboxycyclohex-4-ene derivative represented by the following general formula [I], and its producing method, ##STR1## (where R.sup.1 represents a hydrogen atom, a lower alkyl group, or substituted or unsubstituted aryl group, and R.sup.2 represents a hydrogen atom, or a lower alkyl group). Also provided is a method of producing a (3S, 4R)-4-substituted-3-carboxycyclopentanone derivative represented by the following general formula [A], ##STR2## (where R.sup.1 and R.sup.2 are the same as those mentioned above).

  提供了一种由下列通用式[I]表示的新型(1R,2S)-1-酰基-2-羧基环己-4-烯衍生物及其制备方法：##STR1##（其中，R1代表氢原子、低碳基、取代或未取代的芳基；R2代表氢原子或低碳基）。还提供了一种制备下列通用式[A]所表示的(3S,4R)-4-取代-3-羧基环戊酮衍生物的方法：##STR2##（其中，R1和R2与上述相同）。
• METHOD OF SEPARATING AND PURIFYING TRH ANALOGS AND PROCESS FOR PRODUCING SOLVATES OF TRH ANALOGS
  申请人：Japan Tobacco Inc.

  公开号：EP0749978A1

  公开（公告）日：1996-12-27

  A method for separation and purification of a TRH derivative, which is characterized by introducing an imino-protecting group into the histidine moiety of a TRH analog to give an imino-protected compound of the following formula [II] wherein Y is an imino-protecting group, and separating-purifying same in an organic solvent. According to the present invention, compound [I] can be separated and purified efficiently from the reaction mixture by a simple and easy method. The compound [I] thus obtained can be recrystallized with ease from water and the like as a solvate, thereby permitting easy production of solvate [III] at high purity and in high yields.

  一种分离和纯化 TRH 衍生物的方法，其特征在于在 TRH 类似物的组氨酸中引入一个亚氨基保护基团，得到下式[II]的亚氨基保护化合物 其中 Y 是亚氨基保护基团，并在有机溶剂中分离纯化。根据本发明，化合物[I]可以通过简单易行的方法从反应混合物中有效分离纯化。这样得到的化合物[I]可以很容易地从水中等重结晶为溶质，从而可以很容易地生产出高纯度和高产率的溶质[III]。
• US5151497A
  申请人：——

  公开号：US5151497A

  公开（公告）日：1992-09-29
• Novel peptide derivatives and their pharmaceutical use
  申请人：JAPAN TOBACCO INC.

  公开号：EP0384380B1

  公开（公告）日：1996-06-19