1-(2-bromophenyl)-2-(tetrahydrofuran-2-yl)ethanone | 1248216-03-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-bromophenyl)-2-(tetrahydrofuran-2-yl)ethanone
• 英文别名: 1-(2-Bromophenyl)-2-(oxolan-2-yl)ethanone
• CAS: 1248216-03-6
• 化学式: C₁₂H₁₃BrO₂
• 分子量: 269.138
• InChiKey: MIAFQXRRQNMTGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 2-溴苯乙烯 在 diatomite-supported manganese oxide nanoparticles 、 air 作用下， 反应 12.0h， 以84%的产率得到1-(2-bromophenyl)-2-(tetrahydrofuran-2-yl)ethanone
  参考文献：
  名称：

  Regioselective Oxyalkylation of Vinylarenes Catalyzed by Diatomite-Supported Manganese Oxide Nanoparticles

  摘要：

  A regioselective oxyalkylation reaction of vinylarenes with cyclic ethers was developed under the catalysis of a new heterogeneous catalyst, the diatomite-supported Mn3O4 nanoparticles (SMONP-1). The use of this heterogeneous catalyst provided a novel approach for the synthesis of alpha-carbonyled beta-alkylated aryl derivatives via a sp(3) C-H bond functionalization under mild aerobic conditions.

  DOI：

  10.1021/jo2026367

文献信息

• Regioselective Oxyalkylation of Vinylarenes Catalyzed by Diatomite-Supported Manganese Oxide Nanoparticles
  作者：Huayin Sun、Yonghui Zhang、Fengfeng Guo、Zhenggen Zha、Zhiyong Wang

  DOI：10.1021/jo2026367

  日期：2012.4.6

  A regioselective oxyalkylation reaction of vinylarenes with cyclic ethers was developed under the catalysis of a new heterogeneous catalyst, the diatomite-supported Mn3O4 nanoparticles (SMONP-1). The use of this heterogeneous catalyst provided a novel approach for the synthesis of alpha-carbonyled beta-alkylated aryl derivatives via a sp(3) C-H bond functionalization under mild aerobic conditions.