(2E)-1-[(2S,4S)-2-(4-chloro-5-phenyl-1H-imidazol-2-yl)-4-(4-morpholinyl)-1-pyrrolidinyl]-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-propen-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E)-1-[(2S,4S)-2-(4-chloro-5-phenyl-1H-imidazol-2-yl)-4-(4-morpholinyl)-1-pyrrolidinyl]-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-propen-1-one
• 英文别名: (E)-1-[(2S,4S)-2-(5-chloro-4-phenyl-1H-imidazol-2-yl)-4-morpholin-4-ylpyrrolidin-1-yl]-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-en-1-one
• 化学式: C₂₇H₂₆Cl₂N₈O₂
• 分子量: 565.462
• InChiKey: NSCJNCOPBFVCAR-BASMTRSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SUBSTITUTED PYRROLIDINES AS FACTOR XIA INHIBITORS FOR THE TREATMENT THROMBOEMBOLIC DISEASES
  申请人：Imagawa Akira

  公开号：US20150152048A1

  公开（公告）日：2015-06-04

  The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.

  本发明提供了一般式(I)的化合物，及其盐和N-氧化物，以及它们的溶剂合物和前药（其中取代基如描述中定义）。一般式(I)的化合物是因子XIa的抑制剂，并且在预防和/或治疗血栓栓塞疾病方面具有用途。
• SUBSTITUTED PYRROLIDINES AS FACTOR XIA INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISEASES
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP3056493A1

  公开（公告）日：2016-08-17

  The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.

  本发明提供通式（I）化合物、其盐类和 N-氧化物及其溶液剂和原药（其中取代基如描述中所定义）。通式（I）化合物是因子 XIa 的抑制剂，可用于预防和/或治疗血栓栓塞性疾病。
• Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US10336741B2

  公开（公告）日：2019-07-02

  The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.

  本发明提供通式（I）化合物、其盐类和 N-氧化物及其溶液剂和原药（其中取代基如描述中所定义）。通式（I）化合物是因子 XIa 的抑制剂，可用于预防和/或治疗血栓栓塞性疾病。
• US9394250B2
  申请人：——

  公开号：US9394250B2

  公开（公告）日：2016-07-19
• US9585881B2
  申请人：——

  公开号：US9585881B2

  公开（公告）日：2017-03-07