1-Butyl-3-(3-chlorophenyl)quinolin-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Butyl-3-(3-chlorophenyl)quinolin-1-ium
• 英文别名: 1-butyl-3-(3-chlorophenyl)quinolin-1-ium
• 化学式: C19H19ClN+
• 分子量: 296.8
• InChiKey: OGGLOMNXKPUEAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• INHIBITING MICROBIAL INFECTIONS
  申请人：Egan Susan M.

  公开号：US20140088144A1

  公开（公告）日：2014-03-27

  A method of inhibiting a microbial infection can include: providing a compound of the invention or prodrugs or pharmaceutically acceptable salts thereof; and administering the compound to a subject in a therapeutically effective amount to inhibit the microbial infection. The therapeutically effective amount can be sufficient to inhibit a biological activity of a transcriptional activator of the microbe. The inhibited transcriptional activator is an AraC bacterial transcriptional activator. The AraC bacterial transcriptional activator can be RhaS, RhaR, Rns, or VirF. The microbe can be selected from Vibrio, Pseudomonas , Enterotoxigenic E. coli , and Shigella.