(2R,3S)-2-hydroxy-N-octadecyl-3-[[(E)-3-phenylprop-2-enoyl]amino]butanamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2R,3S)-2-hydroxy-N-octadecyl-3-[[(E)-3-phenylprop-2-enoyl]amino]butanamide
• 化学式: C₃₁H₅₂N₂O₃
• 分子量: 500.8
• InChiKey: DLKWQLZCGBDELL-ISOVHWGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  36
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] SPHINGOLIPID METABOLITE MIMETICS<br/>[FR] MIMÉTIQUES DE MÉTABOLITES SPHINGOLIPIDIQUES
  申请人：UNIV ZHEJIANG

  公开号：WO2014066613A2

  公开（公告）日：2014-05-01

  Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor cells. Further, the sphingolipid metabolite mimetics are shown to be effective at sensitizing multiple types of tumor cells to TRAIL-induced apoptosis. Formulations containing one or more sphingolipid metabolite mimetics and, optionally, one or more cell death receptor agonists are provided. Methods of treating cancer in a subject in need thereof are provided using one or more sphingolipid metabolite mimetics.