9-methoxycarbonyl-4,5-dioxo-2-prop-2-enoxycarbonyl-1H-pyrrolo[2,3-f]quinoline-7-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-methoxycarbonyl-4,5-dioxo-2-prop-2-enoxycarbonyl-1H-pyrrolo[2,3-f]quinoline-7-carboxylic acid
• 化学式: C₁₈H₁₂N₂O₈
• 分子量: 384.3
• InChiKey: KWHJOWOLDKEWRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• SKIN TREATMENTS CONTAINING PYRROLOQUINOLINE QUINONE (PQQ) ESTERS AND METHODS OF PREPARATION AND USE THEREOF
  申请人：Lewis, II Joseph Abernathy

  公开号：US20140178316A1

  公开（公告）日：2014-06-26

  The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

  本发明涉及含有PQQ或其酯的化妆品或皮肤科学组合物，通过这些组合物的局部应用来治疗或促进皮肤变化的方法，以及PQQ酯的合成方法。本发明中含有PQQ酯的组合物在治疗皮肤方面具有出乎意料的有效性，特别是在皮肤耐受性方面。当PQQ酯包含在局部组合物中时，具有抗氧化作用，对于治疗皮肤变化非常有用。
• Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof
  申请人：Lewis, II Joseph Abernathy

  公开号：US10799441B2

  公开（公告）日：2020-10-13

  The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

  本发明涉及含有 PQQ 或其酯的化妆品或皮肤科组合物、通过局部施用这些组合物治疗或促进皮肤变化的方法，以及 PQQ 酯的合成方法。本发明的含 PQQ 酯组合物在治疗皮肤，特别是皮肤耐受性方面具有意想不到的效果。当本发明的PQQ酯包含在局部组合物中时，具有抗氧化作用，可用于治疗皮肤变化。