2-(4-bromophenyl)-N-(2-imidazol-1-ylethyl)quinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-bromophenyl)-N-(2-imidazol-1-ylethyl)quinoline-4-carboxamide
• 化学式: C₂₁H₁₇BrN₄O
• 分子量: 421.3
• InChiKey: IPNFIFXTUONUFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ACTIVATION OR REACTIVATION OF ACHE
  申请人：Stojanovic Milan

  公开号：US20160031854A1

  公开（公告）日：2016-02-04

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACÉTYLCHOLINESTÉRASE
  申请人：UNIV COLUMBIA

  公开号：WO2014113495A1

  公开（公告）日：2014-07-24

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACHE
  申请人：UNIV COLUMBIA

  公开号：WO2014210168A1

  公开（公告）日：2014-12-31

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.