7-[4-(4-benzyl-2-thiophen-3-ylpiperazin-1-yl)butoxy]-1H-quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[4-(4-benzyl-2-thiophen-3-ylpiperazin-1-yl)butoxy]-1H-quinolin-2-one
• 化学式: C₂₈H₃₁N₃O₂S
• 分子量: 473.6
• InChiKey: IOWWJBKBDFIOMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TABLET INCLUDING 7-[4-(4-BENZO[BETA]THIOPHEN-4-YL-PIPERAZIN-1-YL) BUTOXY]-1H-QUINOLIN-2-ONE OR SALT THEREOF
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2767285A1

  公开（公告）日：2014-08-20

  This invention relates to a tablet containing, as an active ingredient, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, that has excellent disintegration ability, storage stability and photostability. The tablet of the present invention comprising an uncoated tablet containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient, excipients such as lactose, corn starch, and microcrystalline cellulose; disintegrants such as low-substituted hydroxypropylcellulose, croscarmellose sodium, and sodium carboxymethyl starch; binders such as hydroxypropylcellulose; lubricants such as stearate; and further comprising a coating layer containing hypromellose; talc; titanium oxide; colorant; and the like, the coating layer being applied to the surface of the uncoated tablet.

  本发明涉及一种含有 7-[4-(4-苯并[b]噻吩-4-基-哌嗪-1-基)丁氧基]-1H-喹啉-2-酮或其盐作为活性成分的片剂，该片剂具有良好的崩解能力、储存稳定性和光稳定性。 本发明的片剂包括含有 7-[4-(4-苯并[b]噻吩-4-基-哌嗪-1-基)丁氧基]-1H-喹啉-2-酮或其盐作为活性成分的无包衣片剂，辅料如乳糖、玉米淀粉和微晶纤维素；崩解剂，如低取代羟丙基纤维素、croscarmellose sodium 和羧甲基淀粉钠； 粘合剂，如羟丙基纤维素； 润滑剂，如硬脂酸盐； 还包括一层包衣，包衣层含有低聚果糖、滑石粉、氧化钛、着色剂等，包衣层涂在未包衣片剂的表面。
• EP2767285A4
  申请人：——

  公开号：EP2767285A4

  公开（公告）日：2015-03-11