benzene-1,2-diol;(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: benzene-1,2-diol;(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
• 化学式: C15H14O6
• 分子量: 290.27
• InChiKey: DXHQUMUWFKOZEQ-VEELZWTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] BIOSYNTHESIS OF O-METHYLATED PHENOLIC COMPOUNDS<br/>[FR] BIOSYNTHÈSE DE COMPOSÉS PHÉNOLIQUES O-MÉTHYLÉS
  申请人：EVIAGENICS S A

  公开号：WO2014128252A1

  公开（公告）日：2014-08-28

  The invention provides for a process for biosynthesis of an O-methylated compound by biotransforming a compound of Formula I into an O-methylated compound, wherein R1 is H, CHO, COOH, C1-6alkyl-COOH, or C2-6 alkenyl-COOH; R2 is H, OH, or OCH3; which process comprises the steps: a) providing a recombinant host cell comprising i) at least one first heterologous gene encoding a first enzyme which is a 4-O-1 methyltransferase operable to biotransform the compound into a 4-O-methylated compound; and ii) optionally, if R2 is OH, at least one second heterologous gene encoding a second enzyme which is a 3-O-methyltransferase, wherein said first and second enzymes are operable to biotransform the compound into a 3,4-O-dimethylated compound; b) cultivating said host cell to express said first and optionally said second enzyme; c) providing the compound and biotransforming the compound into a 4-O-methylated compound or if R2 is OH, into a 3,4-O-dimethylated compound.