3-amino-3-deoxy-D-glucose; hydrochloride | 57649-10-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-amino-3-deoxy-D-glucose; hydrochloride
• 英文别名: 3-Amino-3-desoxy-D-glucose; Hydrochlorid；(2R,3S,4S,5R)-3-amino-2,4,5,6-tetrahydroxyhexanal;hydron;chloride
• CAS: 57649-10-2
• 化学式: C₆H₁₃NO₅*ClH
• 分子量: 215.634
• InChiKey: ADFOMBKCPIMCOO-BTVCFUMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.99
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  124
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-amino-3-deoxy-D-glucose; hydrochloride 、 甲基丙烯酰氯 在 盐酸 、 sodium methylate 、 sodium 作用下， 以 甲醇 为溶剂， 生成 3-N-methacrylamido-3-deoxy-D-glucose
  参考文献：
  名称：

  Method for stabilizing proteins with saccharide linked protein polymer

  摘要：

  本方法公开了一种制备水溶性蛋白质聚合物共轭物的方法，该方法通过至少三个连接剂共价键合聚合物到蛋白质上，这些连接剂具有三个或更多的羟基。蛋白质在赖氨酸或精氨酸上共轭。此方法可以使蛋白质在恶劣环境中保持功能性。

  公开号：

  US05736625A1

文献信息

• Glucose conjugated gold nanoparticle
  申请人：Bar-Ilan University

  公开号：US10478132B2

  公开（公告）日：2019-11-19

  Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.

  用于诊断和治疗受试者体内肿瘤的组合物方法和试剂盒。所公开的组合物包括：金纳米粒子；PEG 或其衍生物，其中所述 PEG 或其衍生物的分子量为 400 至 1500 道尔顿；以及 2-脱氧-D-葡萄糖，其中所述 PEG 或其衍生物与金纳米粒子和所述 2-脱氧-D-葡萄糖相连，并且所述 2-脱氧-D-葡萄糖在 2-脱氧-D-葡萄糖的 2 碳位置与 PEG 或其衍生物相连。
• CONJUGATES OF POLY(VINYLSACCHARIDE) WITH PROTEINS FOR THE STABILIZATION OF PROTEINS
  申请人：CARGILL, INCORPORATED

  公开号：EP0513332A1

  公开（公告）日：1992-11-19
• EP0513332A4
  申请人：——

  公开号：EP0513332A4

  公开（公告）日：1993-03-17
• GLUCOSE CONJUGATED GOLD NANOPARTICLE
  申请人：Bar-Ilan University

  公开号：US20170189560A1

  公开（公告）日：2017-07-06

  Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.
• Complex Human Gut Microbiome Cultured In An Anaerobic Human Gut-On-A-Chip
  申请人：President and Fellows of Harvard College

  公开号：US20210079356A1

  公开（公告）日：2021-03-18

  A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.