6-[5-[(5-fluoropyridin-2-yl)oxymethyl]pyridin-3-yl]-1-methyl-3,4-dihydro-2H-quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[5-[(5-fluoropyridin-2-yl)oxymethyl]pyridin-3-yl]-1-methyl-3,4-dihydro-2H-quinoline
• 化学式: C₂₁H₂₀FN₃O
• 分子量: 349.4
• InChiKey: KFCDAXUSCLZULT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP1 1 B2 OR CYP1 1 B1 ) INHIBITORS
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2964628A1

  公开（公告）日：2016-01-13
• [EN] NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP1 1 B2 OR CYP1 1 B1 ) INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS DE DIHYDROQUINOLINE-2-ONE EN TANT QU'INHIBITEURS D'ALDOSTÉRONE SYNTHASE (CYP1 1 B2 OU CYP1 1 B1)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014135561A1

  公开（公告）日：2014-09-12

  The invention provides novel compounds having the general formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R11 and A are as described herein, compositions including the compounds and methods of using the compounds. The compounds of formula (I) are useful as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment of various disorders.