2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)cyclohexanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)cyclohexanone
• 英文别名: 1-(4-chloro-phenyl)-3-(2-oxo-cyclohexyl)-3-phenyl-propan-1-one；1-(4-Chlor-phenyl)-3-(2-oxo-cyclohexyl)-3-phenyl-propan-1-on；2-[3-(4-Chlorophenyl)-3-oxo-1-phenylpropyl]cyclohexan-1-one
• 化学式: C₂₁H₂₁ClO₂
• mdl: MFCD02731011
• 分子量: 340.85
• InChiKey: LTUOTVKMCFICON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)cyclohexanone 在 ammonium acetate 、 溶剂黄146 作用下， 以98%的产率得到2-(4-chlorophenyl)-4-phenyl-5,6,7,8-tetrahydroquinoline
  参考文献：
  名称：

  三步合成2,4-二芳基-5,6,7,8-四氢喹啉衍生物

  摘要：

  除环己酮，以查耳酮，从相应的苯乙酮和苯甲醛衍生物得到的，无溶剂的条件下的，得到在良好的产率1,5-二酮类。1,5-二酮的治疗乙酸中的乙酸铵直接提供2,4-二芳基-5,6,7,8-四氢喹啉衍生物高产。的结构通过1 H NMR，13 C NMR，IR和元素分析来阐明。J.杂环化​​学。（2010）。

  DOI：

  10.1002/jhet.409
• 作为产物：
  描述：

  环己酮 、 4'-chlorochalcone 在 苄基三乙基氯化铵 、 水 、 potassium hydroxide 作用下， 以72%的产率得到2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)cyclohexanone
  参考文献：
  名称：

  三步合成2,4-二芳基-5,6,7,8-四氢喹啉衍生物

  摘要：

  除环己酮，以查耳酮，从相应的苯乙酮和苯甲醛衍生物得到的，无溶剂的条件下的，得到在良好的产率1,5-二酮类。1,5-二酮的治疗乙酸中的乙酸铵直接提供2,4-二芳基-5,6,7,8-四氢喹啉衍生物高产。的结构通过1 H NMR，13 C NMR，IR和元素分析来阐明。J.杂环化​​学。（2010）。

  DOI：

  10.1002/jhet.409

文献信息

• Highly enantioselective Michael addition of cyclic ketones to chalcones catalyzed by pyrrolidine-based imides
  作者：Hong-Yu Xie、Shu-Rong Ban、Ju-Na Liu、Qing-Shan Li

  DOI：10.1016/j.tetlet.2012.05.106

  日期：2012.7

  An efficient procedure for asymmetric Michael addition reaction of cyclic ketones with low activated chalcones catalyzed by pyrrolidine-based phthalimide and 1,8-Naphthalimide catalysts was developed. The corresponding products were obtained in high yields with high diastereoselectivities (up to 99:1 dr) and high enantioselectivities (up to 96% ee) under mild conditions.

  研究了吡咯烷基邻苯二甲酰亚胺和1,8-萘二甲酰亚胺催化剂催化环状酮与低活化查耳酮不对称迈克尔加成反应的有效方法。在温和条件下，以高收率获得了具有高非对映选择性（高达99：1 dr）和高对映选择性（高达96％ee）的相应产品。
• Direct asymmetric Michael addition of ketones to chalcones catalyzed by a hydroxyphthalimide derived triazole–pyrrolidine
  作者：Togapur Pavan Kumar、Mohammad Abdul Sattar、Vanka Uma Maheshwara Sarma

  DOI：10.1016/j.tetasy.2013.11.002

  日期：2013.12

  An efficient protocol for the enantioselective Michael additions of ketones to chalcones catalyzed by a hydroxyphthalimide linked triazole-pyrrolidine derivative has been developed. The corresponding products, 1,5-dicarbonyl compounds, were obtained in good yields with high levels of stereoselectivities under mild reaction conditions employing benzoic acid as an additive. (C) 2013 Elsevier Ltd. All rights reserved.
• Cohesion in science lesson discourse: clarity, relevance and sufficient information
  作者：Susan Rodrigues、Ian Thompson

  DOI：10.1080/09500690010025076

  日期：2001.9

  This paper discusses linguistics in the teaching of science, specifically the key linguistic processes through which students learn, rather than the mechanics of classroom interaction. Integrated datasets from The Classroom Learning Project contain transcripts of videotaped lessons spliced with teacher and student interviews and annotated with a researcher's comments. To illustrate the role of language in determining the effectiveness of teaching and learning, an integrated data set for one Australian Year 9 (14 year old students) science lesson on 'Fibres and Fabrics' was analysed in terms of coherence and comprehension. The analysis demonstrates the importance of communication skills in the classroom and the value of language analysis in determining the effectiveness of teacher's instructions. This paper argues the need for teachers to consider the importance of learning as a linguistic milieu especially when teaching science in context. When teaching and learning in contextually, competent communication must include adequate, genuine, clear and relevant amounts of information.
• A mild and efficient procedure for asymmetric Michael additions of cyclohexanone to chalcones catalyzed by an amino acid ionic liquid
  作者：Yunbo Qian、Shiyong Xiao、Lei Liu、Yongmei Wang

  DOI：10.1016/j.tetasy.2008.06.022

  日期：2008.7

  A mild and efficient procedure for Michael additions of cyclohexanone to chalcones has been developed. In the presence of amino acid ionic liquid [EMlm][Pro] (200 mol %), cyclohexanone reacted with various chalcones to afford Michael adducts in high yields (85-98%) and moderate to good enantioselectivities (16-94% ee), accompanied by an unexpected solvent-dependent inversion of the enantioselectivity. (C) 2008 Elsevier Ltd. All rights reserved.
• The Synthesis of New Organoselenium Heterocyclic Compounds: 2-aryl-4-phenyl-5,6,7,8-tetrahydro-4H-selenochromenes
  作者：Dmitriy Yurievich Direnko、Yaroslav Borisovich Drevko、Boris Ivanovich Drevko

  DOI：10.1002/jccs.201500406

  日期：2015.12

  AbstractWe have explored the reactions of 2‐(3‐oxo‐1‐aryl‐3‐phenylpropyl)cyclohexanone (1–3) with hydrogen selenide in situ in conditions of acid catalysis, and synthesized new 2‐aryl‐4‐phenyl‐5,6,7,8‐tetrahydro‐4H‐selenochromenes (4–6).