4-Hydroxy-1-methyl-3-(toluene-4-sulfonyl)-1H-quinolin-2-one | 477204-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Hydroxy-1-methyl-3-(toluene-4-sulfonyl)-1H-quinolin-2-one
• 英文别名: 4-Hydroxy-1-methyl-3-(p-tolylsulfonyl)quinolin-2-one；4-hydroxy-1-methyl-3-(4-methylphenyl)sulfonylquinolin-2-one
• CAS: 477204-90-3
• 化学式: C₁₇H₁₅NO₄S
• 分子量: 329.376
• InChiKey: VVCWJCSCUGDPJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲基苯唑 在 盐酸 作用下， 以 异丁酰胺 、 mineral oil 为溶剂， 以5.7 g (43%)的产率得到4-Hydroxy-1-methyl-3-(toluene-4-sulfonyl)-1H-quinolin-2-one
  参考文献：
  名称：

  Inhibitors of macrophage migration inhibitory factor and methods for identifying the same

  摘要：

  提供了MIF的抑制剂，对治疗各种疾病具有实用性，包括与MIF活性相关的病理条件的治疗。MIF的抑制剂具有以下结构：包括立体异构体、前药和其药用盐，其中n、R1、R2、R3、R4、X、Y和Z如本文所定义。还提供了含有MIF抑制剂的组合物，与药用载体结合，以及使用方法。

  公开号：

  US20030195194A1

文献信息

• INHIBITORS OF MACROPHASE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME
  申请人：Gaeta C.A. Federico

  公开号：US20060094727A1

  公开（公告）日：2006-05-04

  Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

  提供了MIF抑制剂，其在治疗各种疾病方面具有用途，包括治疗与MIF活性相关的病理状况。MIF抑制剂具有以下结构：包括立体异构体，前药和其药学上可接受的盐，其中n，R1，R2，R3，R4，X，Y和Z如本文所定义。还提供了含有MIF抑制剂和药学上可接受的载体的组合物，以及使用它们的方法。
• INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME
  申请人：Gaeta C.A. Federico

  公开号：US20060194793A1

  公开（公告）日：2006-08-31

  Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

  提供了MIF抑制剂，具有治疗各种疾病的功效，包括治疗与MIF活性相关的病理条件。MIF抑制剂具有以下结构：包括立体异构体，前药和其药学上可接受的盐，其中n，R1，R2，R3，R4，X，Y和Z的定义如本文所述。同时还提供了含有MIF抑制剂和药学上可接受的载体的组合物，以及使用它们的方法。
• Inhibitors of macrophage migration inhibitory factor and methods for indentifying the same
  申请人：Gaeta C.A. Federice

  公开号：US20060235023A1

  公开（公告）日：2006-10-19

  Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

  提供了MIF的抑制剂，可用于治疗多种疾病，包括与MIF活性相关的病理条件的治疗。MIF的抑制剂具有以下结构：包括立体异构体、前药和其药学上可接受的盐，其中n、R1、R2、R3、R4、X、Y和Z的定义如本文所述。还提供了含有MIF抑制剂与药学上可接受的载体组合的组合物，以及使用它们的方法。
• US7084141B2
  申请人：——

  公开号：US7084141B2

  公开（公告）日：2006-08-01
• US7105519B2
  申请人：——

  公开号：US7105519B2

  公开（公告）日：2006-09-12