4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)-ethyl]-tetrahydro-pyran-2-one | 94667-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)-ethyl]-tetrahydro-pyran-2-one
• 英文别名: 4-(tert-Butyldimethylsilanyloxy)-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl]tetrahydropyran-2-one；4-[tert-butyl(dimethyl)silyl]oxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl]oxan-2-one
• CAS: 94667-54-6
• 化学式: C₂₅H₄₂O₄Si
• 分子量: 434.692
• InChiKey: MJLUKJALEPACMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)-ethyl]-tetrahydro-pyran-2-one 、 三氯乙酰氯 生成 [8-[2-[4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2,2-trichloroacetate
  参考文献：
  名称：

  KUVATA, BAN;ARAKAVA, MORIMASA;OGI, TOKIO;FUDZIMOTO, YASUO

  摘要：

  DOI：

文献信息

• Lymphocyte function antigen-1 antagonists
  申请人：Novartis AG

  公开号：US06630492B1

  公开（公告）日：2003-10-07

  Mevinolin compounds for use in the treatment or prevention of autoimmune diseases, inflammation, ischemia/reperfusion injury and graft rejection. Such compounds bind to the LFA-1 I-domain and thereby inhibit LFA-1/ICAM-1 or LFA-1/ICAM-3 interactions.

  Mevinolin化合物可用于治疗或预防自身免疫性疾病、炎症、缺血/再灌注损伤和移植排斥。这些化合物结合到LFA-1 I-域，从而抑制LFA-1/ICAM-1或LFA-1/ICAM-3的相互作用。
• Antipsoriatic agents
  申请人：Hoffman-La Roche Inc.

  公开号：US05200549A1

  公开（公告）日：1993-04-06

  The invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl; ##STR2## wherein R.sub.2 is lower alkyl; R.sub.3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R.sub.4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR3## and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as described above; or a pharmaceutically acceptable salt of said acid, a C.sub.1-4 alkyl ester of said acid, an acetylamino-substituted-C.sub.1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a .alpha.-monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.

  本发明涉及公式## STR1 ##的化合物，其中R.sub.1是氢或甲基; ## STR2 ##其中R.sub.2是较低的烷基; R.sub.3是苯基，或苯基取代物，取代物由卤素，较低的烷基和较低的烷氧基中选择1至3个取代基组成; R.sub.4是氢或甲基或公式## STR3 ##的相应羟基酸，其中R.sub.1，R.sub.2，R.sub.3和R.sub.4如上所述;或该酸的药学上可接受的盐，该酸的C.sub.1-4烷基酯，该酸的乙酰氨基取代的C.sub.1-4烷基酯，该酸的苯基二甲基氨基酯或该酸的α-单甘油酯。公式I和II的化合物可用于治疗过度增生性皮肤疾病，如银屑病。