2-(3-Fluoroquinolin-5-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(3-Fluoroquinolin-5-yl)acetamide
• 英文别名: 2-(3-fluoroquinolin-5-yl)acetamide
• 化学式: C₁₁H₉FN₂O
• 分子量: 204.2
• InChiKey: ZGJLXPUFOFHGCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF JUN N-TERMINAL KINASE
  申请人：IMAGO PHARMACEUTICALS, INC.

  公开号：US20180319780A1

  公开（公告）日：2018-11-08

  The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, C a , C b , Z, R 5 , W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.