Chicoric acid analogues and derivatives have activity against HIV-1 integrase. The structural features that are required for this activity are elucidated by assaying these analogues and derivatives against HIV-1 integrase. Furthermore, methods of synthesis of the enantiomers of chicoric acid itself, as well as its analogues and derivatives, are disclosed. Additionally, methods of use of chicoric acid analogues and derivatives to inhibit HIV-1 integrase are disclosed, as are compositions comprising chicoric acid analogues and derivatives.
Chicoric酸类似物和衍
生物具有抗HIV-1整合酶的活性。通过对这些类似物和衍
生物对HIV-1整合酶的测定,阐明了实现这种活性所需的结构特征。此外,还公开了合成Chicoric酸本身及其类似物和衍
生物的对映体的方法。此外,还公开了使用Chicoric酸类似物和衍
生物抑制HIV-1整合酶的方法,以及包含Chicoric酸类似物和衍
生物的组合物。