Methyl 3-(4-fluorophenyl)-2-(furan-2-yl)quinoline-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 3-(4-fluorophenyl)-2-(furan-2-yl)quinoline-4-carboxylate
• 英文别名: methyl 3-(4-fluorophenyl)-2-(furan-2-yl)quinoline-4-carboxylate
• 化学式: C₂₁H₁₄FNO₃
• 分子量: 347.3
• InChiKey: ILEDBFLVTBCVIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
  申请人：Molecular Templates, Inc.

  公开号：US10421958B2

  公开（公告）日：2019-09-24

  The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the interim reduction or elimination of ribotoxicity and the methods can identify cytotoxic molecules, each comprising a binding region and a ribotoxic region which jointly possess a desired assay-selectable characteristic, such as, e.g., binding to a target biomolecule, binding to a target cell, and/or cellular internalization.

  本发明涉及筛选包含核糖核酸毒性多肽的嵌合分子库的方法，其中筛选是基于核糖核酸毒性的临时减少或消除，该方法可以鉴定细胞毒性分子，每个分子都包含一个结合区和一个核糖核酸毒性区，它们共同具有所需的可测定选择的特性，例如，与靶生物大分子结合、与靶细胞结合和/或细胞内化。
• METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY
  申请人：Molecular Templates, Inc.

  公开号：EP3102245B1

  公开（公告）日：2021-09-08
• [EN] METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY<br/>[FR] PROCÉDÉS DE CRIBLAGE, DE SÉLECTION ET D'IDENTIFICATION DE POLYPEPTIDES DE RECOMBINAISON CYTOTOXIQUES FONDÉS SUR UNE DIMINUTION PROVISOIRE DE LA RIBOTOXICITÉ
  申请人：MOLECULAR TEMPLATES INC

  公开号：WO2015120058A2

  公开（公告）日：2015-08-13

  The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the interim reduction or elimination of ribotoxicity and the methods can identify cytotoxic molecules, each comprising a binding region and a ribotoxic region which jointly possess a desired assay-selectable characteristic, such as, e.g., binding to a target biomolecule, binding to a target cell, and/or cellular internalization.