N,N-dimethyl-2-(quinolin-4'-ylthio)ethylamine | 104818-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-dimethyl-2-(quinolin-4'-ylthio)ethylamine
• 英文别名: N,N-dimethyl-2-quinolin-4-ylsulfanylethanamine
• CAS: 104818-98-6
• 化学式: C₁₃H₁₆N₂S
• 分子量: 232.349
• InChiKey: CGWMVBJNPRXCCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基喹啉 在 氢氧化钾 、 tetraphosphorus decasulfide 作用下， 以 吡啶 、 甲苯 为溶剂， 反应 3.0h， 生成 N,N-dimethyl-2-(quinolin-4'-ylthio)ethylamine
  参考文献：
  名称：

  Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

  摘要：

  4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from H-1 and C-13 NMR spectra. These drugs were tested against selected gram-, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80076-2

文献信息

• Heterocyclic Amplifiers of Phleomycin. IX. Some Derivatives of Fused and Unfused Mono- and Di-aza Heterocycles
  作者：GB Barlin、SJ Ireland

  DOI：10.1071/ch9851685

  日期：——

  Some mono- and bis-dimethylaminoethylthio, dimethylaminopropylthio and carbamoylmethylthio derivatives of pyridine, pyridazine , 1,3,4- thiadiazole , thiazoline , quinoline , quinoxaline , quinazoline , phthalazine , 6-nitrobenzothiazole and benzimidazo [1,2-c] quinazoline have been prepared for testing as amplifiers of phleomycin. These compounds showed relatively low activity; the highest activity was shown by 4-(2′-dimethylaminoethylthio) quinoline at three star, but a number were antibacterial under the test conditions.

  制备了吡啶、哒嗪、1,3,4-噻二唑、噻唑啉、喹啉、喹喔啉、喹唑啉、酞嗪、6-硝基苯并噻唑和苯并咪唑并[1,2-c]喹唑啉的一些单二甲胺基乙硫基、二甲胺基丙硫基和氨基甲酰甲硫基衍生物，并将其作为弗来霉素的放大剂进行试验。这些化合物的活性相对较低；4-（2′-二甲氨基乙硫基）喹啉的活性最高，为 3 星，但在试验条件下，一些化合物具有抗菌作用。
• BARLIN, G. B.;IRELAND, S. J., AUSTRAL. J. CHEM., 1985, 38, N 11, 1685-1691
  作者：BARLIN, G. B.、IRELAND, S. J.

  DOI：——

  日期：——
• Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives
  作者：Marie-Gratia Kayirere、Abdallah Mahamoud、Jacqueline Chevalier、Jean-Claude Soyfer、Andrée Crémieux、Jacques Barbe

  DOI：10.1016/s0223-5234(99)80076-2

  日期：1998.1

  4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from H-1 and C-13 NMR spectra. These drugs were tested against selected gram-, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.