[2-(cyclopropylamino)-2-oxoethyl] (4E)-4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [2-(cyclopropylamino)-2-oxoethyl] (4E)-4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylate
• 化学式: C₂₄H₂₂N₂O₃S
• 分子量: 418.5
• InChiKey: XVAZLIFYXAMQAX-FYWRMAATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Inhibitors Of Protein Phosphatase-1 And Uses Thereof
  申请人：Nekhai Sergei

  公开号：US20090264463A1

  公开（公告）日：2009-10-22

  Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
• Inhibitors of Protein Phosphatase-1 and Uses Thereof
  申请人：HOWARD UNIVERSITY

  公开号：US20160024013A1

  公开（公告）日：2016-01-28

  Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
• US8278326B2
  申请人：——

  公开号：US8278326B2

  公开（公告）日：2012-10-02
• US9447047B2
  申请人：——

  公开号：US9447047B2

  公开（公告）日：2016-09-20